PROTAC ER Degrader-4 CAS#: 2361114-15-8

PROTAC ER Degrader-4 Basic information

Product Name:

PROTAC ER Degrader-4

Synonyms:

PROTAC ER Degrader-4
(2S,4R)-1-[(2S)-2-(2-{2-[2-(2-{3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indol-1-yl]phenoxy}ethoxy)ethoxy]ethoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

CAS:

2361114-15-8

MF:

C53H67F3N6O8S

MW:

1005.19

Mol File:

Mol File

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PROTAC ER Degrader-4 Chemical Properties

Boiling point:: 1038.9±65.0 °C(Predicted)
Density: 1.254±0.06 g/cm3(Predicted)
pka: 13.54±0.46(Predicted)
form: Solid
color: Light yellow to yellow

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PROTAC ER Degrader-4 Usage And Synthesis

Biological Activity

PROTAC ER Degrader-4 is a von Hippel-Lindau-based PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1]. PROTAC ER Degrader-4 shows equal to 100% ER degradation at 0.3 μM in the MCF-7 ER degradation cellular assay[1].

References

[1]. Bin Yang, et al. Compounds and their use in treating cancer. WO2019123367A1.

PROTAC ER Degrader-4Supplier

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Email: 3003855609@qq.com

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com

Changzhou Bojia Biomedical Technology Co., Ltd.

Tel: 2122619822
Email: czbjpharma@126.com

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054 13417589054
Email: trendseenbio@gmail.com

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