PROTAC FKBP Degrader-3 CAS#: 2079056-43-0

PROTAC FKBP Degrader-3 Basic information

Product Name:

PROTAC FKBP Degrader-3

Synonyms:

PROTAC FKBP Degrader-3
(1R)-3-(3,4-dimethoxyphenyl)-1-(3-{[(2-{2-[2-({[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}methoxy)ethoxy]ethoxy}ethyl)carbamoyl]methoxy}phenyl)propyl (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate

CAS:

2079056-43-0

MF:

C68H90N6O17S

MW:

1295.54

Mol File:

2079056-43-0.mol

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PROTAC FKBP Degrader-3 Chemical Properties

Boiling point:: 1297.9±65.0 °C(Predicted)
Density: 1.233±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 25 mg/mL (19.30 mM)
form: Solid
pka: 13.54±0.46(Predicted)
color: Off-white to light yellow

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PROTAC FKBP Degrader-3 Usage And Synthesis

Uses

PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an von Hippel-Lindau binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].

IC 50

VHL; FKBP

References

[1] Ottis P, et al. Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS Chem Biol. 2017 Oct 20;12(10):2570-2578. DOI:10.1021/acschembio.7b00485

PROTAC FKBP Degrader-3Supplier

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Email: 3003855609@qq.com

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Email: sales@chemegen.com

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988941452
Email: YN_research@163.com

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