(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one Chemical Properties

storage temp. 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility 

DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml

form 

Liquid

color 

Colorless to light yellow

LogP

1.775 (est)

(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one Usage And Synthesis

Description

Senkyunolide A is a phthalide originally isolated from celery seed essential oil that has cytoprotective and antiproliferative activities. It protects against cell injury induced by corticosterone in PC12 cells in a time-dependent manner when used at concentrations ranging from 0.125 to 0.5 mg/ml and reduces corticosterone-induced apoptosis at a concentration of 0.5 mg/ml. It also reverses increases in protein levels of phosphatase 2A (PP2A) and α-synuclein and reverses decreases in the phosphorylated forms of PP2A and α-synuclein. Senkyunolide A inhibits cell proliferation of HT-29 colon cancer (IC₅₀ = 54.17 μM) but not non-cancerous human CCD-18Co colon cells (IC₅₀ = 109.11 μM).

Chemical Properties

A slightly yellow oily substance, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the rhizome of Chuanxiong.

Definition

ChEBI: Senkyunolide is a member of 2-benzofurans.

References

[1] LEONARD F. BJELDANES  In S K. Phthalide components of celery essential oil[J]. The Journal of Organic Chemistry, 1977, 42 13: 2333-2335. DOI: 10.1021/jo00433a033
[2] SHENGLAN GONG. Senkyunolide A protects corticosterone-induced cell apoptosis via modulating protein phosphatase 2A and α-synuclein[J]. bioRxiv?: the preprint server for biology, 2017, 24 1. DOI: 10.1101/145326
[3] WINNIE LAI TING KAN. Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells[J]. Journal of ethnopharmacology, 2008, 120 1: Pages 36-43. DOI: 10.1016/j.jep.2008.07.027

(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one(63038-10-8)Related Product Information

• 3-[(Z)-Butylidene]-5-hydroxyisobenzofuran-1(3H)-one
• Ethyl 4-hydroxy-3-methoxycinnamate
• Z-LIGUSTILIDE
• trans-Ferulic acid
• Ligustrazine Hydrochloride
• Angelicolide
• N-BUTYLIDENEPHTHALIDE
• Scutellarin
• RHOIFOLIN
• ABSINTHIN
• Senkyunolide I
• SCUTELLAREIN
• Myricetin
• MONOCROTALINE
• oxypaeoniflora
• Myricitrin
• Ammothamnine
• Senkyunolide H