(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one Chemical Properties

storage temp. 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility 

DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml

form 

Liquid

color 

Colorless to light yellow

LogP

1.775 (est)

(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one Usage And Synthesis

Description

Senkyunolide A is a phthalide originally isolated from celery seed essential oil that has cytoprotective and antiproliferative activities. It protects against cell injury induced by corticosterone in PC12 cells in a time-dependent manner when used at concentrations ranging from 0.125 to 0.5 mg/ml and reduces corticosterone-induced apoptosis at a concentration of 0.5 mg/ml. It also reverses increases in protein levels of phosphatase 2A (PP2A) and α-synuclein and reverses decreases in the phosphorylated forms of PP2A and α-synuclein. Senkyunolide A inhibits cell proliferation of HT-29 colon cancer (IC₅₀ = 54.17 μM) but not non-cancerous human CCD-18Co colon cells (IC₅₀ = 109.11 μM).

Definition

ChEBI: Senkyunolide is a member of 2-benzofurans.

(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one(63038-10-8)Related Product Information

• 3-[(Z)-Butylidene]-5-hydroxyisobenzofuran-1(3H)-one
• Ethyl 4-hydroxy-3-methoxycinnamate
• Z-LIGUSTILIDE
• trans-Ferulic acid
• Ligustrazine Hydrochloride
• Angelicolide
• N-BUTYLIDENEPHTHALIDE
• Scutellarin
• RHOIFOLIN
• ABSINTHIN
• Senkyunolide I
• SCUTELLAREIN
• Myricetin
• MONOCROTALINE
• oxypaeoniflora
• Myricitrin
• Ammothamnine
• Senkyunolide H