Basic information Safety Supplier Related

(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one

Basic information Safety Supplier Related

(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one Basic information

Product Name:
(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one
Synonyms:
  • (3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one
  • (S)-3-Butyl-4,5-dihydroisobenzofuran-1(3H)-one
  • Senkyunolide
  • 1(3H)-Isobenzofuranone, 3-butyl-4,5-dihydro-, (S)-
  • (-)-Sedanenolide
  • (3S)-3-Butyl-4,5-dihydro-1(3H)-isobenzofuranone
  • (S)-Sedanenolide
  • Sedanenolide
CAS:
63038-10-8
MF:
C12H16O2
MW:
192.26
Mol File:
63038-10-8.mol
More
Less

(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one Chemical Properties

storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
LogP
1.775 (est)
More
Less

(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one Usage And Synthesis

Description

Senkyunolide A is a phthalide originally isolated from celery seed essential oil that has cytoprotective and antiproliferative activities. It protects against cell injury induced by corticosterone in PC12 cells in a time-dependent manner when used at concentrations ranging from 0.125 to 0.5 mg/ml and reduces corticosterone-induced apoptosis at a concentration of 0.5 mg/ml. It also reverses increases in protein levels of phosphatase 2A (PP2A) and α-synuclein and reverses decreases in the phosphorylated forms of PP2A and α-synuclein. Senkyunolide A inhibits cell proliferation of HT-29 colon cancer (IC50 = 54.17 μM) but not non-cancerous human CCD-18Co colon cells (IC50 = 109.11 μM).

Definition

ChEBI: Senkyunolide is a member of 2-benzofurans.

(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-oneSupplier

BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Email
y.liu@mail.biobiopha.com
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Email
cwb1@biopurify.cn
Vientiane Tianjin Hengyuan Technology Co., Ltd.
Tel
15722085254
Email
phytochemical@126.com
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Email
sales@reading-chemicals.com
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Email
aileen@chemfaces.com