oxypaeoniflora
oxypaeoniflora Basic information
- Product Name:
- oxypaeoniflora
- Synonyms:
-
- oxypaeoniflora
- oxypaeoniflorin
- [[(1aR)-3aβ,5,5aβ,5b-Tetrahydro-5β-hydroxy-5bβ-[[(4-hydroxybenzoyl)oxy]methyl]-2-methyl-2α,5-methano-3,4-dioxa-1H-cyclobuta[cd]pentalen]-1aβ(2H)-yl]β-D-glucopyranoside
- Nsc258310
- Oxypeoniflorin
- Oxypaeoniflorin, >98%
- β-D-Glucopyranoside, (1aR,2S,3aR,5R,5aR,5bS)-tetrahydro-5-hydroxy-5b-[[(4-hydroxybenzoyl)oxy]methyl]-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl
- ((2S,2aR,2a1S,3aR,4R,5aR)-4-hydroxy-2-methyl-2a-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-1,5-dioxa-2,4-methanocyclobuta[cd]pentalen-2a1-yl)methyl 4-hydroxybenzoate
- CAS:
- 39011-91-1
- MF:
- C23H28O12
- MW:
- 496.46
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- The group of Paeoniflorin
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 39011-91-1.mol
oxypaeoniflora Chemical Properties
- Melting point:
- >162°C (dec.)
- Boiling point:
- 737.1±60.0 °C(Predicted)
- Density
- 1.71±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 8.16±0.15(Predicted)
- color
- White to Pale Yellow
- Stability:
- Hygroscopic
oxypaeoniflora Usage And Synthesis
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from peony bark, peony root, and red peony root.
Uses
Oxypaeoniflora is a plant extract of Paeonia suffruticosa, and has been used in the prevention of pathogenesis diabetic nephropathy providing anti-oxidative and anti-inflammatory activity.
Definition
ChEBI: Oxypaeoniflorin is a monoterpene glycoside with formula C23H28O12, isolated from several species of Paeoniae. It has a role as a plant metabolite. It is a cyclic acetal, a lactol, a bridged compound, a beta-D-glucoside, a 4-hydroxybenzoate ester and a monoterpene glycoside.
in vivo
Oxypaeoniflorin (OPA; 10-40 mg/kg; intragastrical administration; every day; for 30 days) treatment significantly reduces disruption of cardiac function and improves the indicators of ejection fraction (EF) and fractional shortening (FS). Oxypaeoniflorin significantly reduces the release of myocardial infarction-related factors, such as the creatine kinase (CK-MB), cardiac troponin I (cTnI) and cardiac troponin T (cTnT)[1].
| Animal Model: | C57BL/6 male mice (6-8 weeks of age, 20-25 g) bearing myocardial ischemia/reperfusion (MI/R) injury[1] |
| Dosage: | 10 mg/kg, 20 mg/kg, 40 mg/kg |
| Administration: | Intragastrical administration; every day; for 30 days |
| Result: | Significantly reduced disruption of cardiac function and improved the indicators of ejection fraction (EF) and fractional shortening (FS). |
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