PROCYANIDIN B3
PROCYANIDIN B3 Basic information
- Product Name:
- PROCYANIDIN B3
- Synonyms:
-
- [4,8''-Biflavan]-3,3',3'',3''',4',4''',5,5'',7,7''-decol stereoisomer
- Procyanidol B3
- (2R,2'R,3S,3'S,4S)-2,2'-Bis(3,4-dihydroxyphenyl)-[4,8'-bichroman]-3,3',5,5',7,7'-hexaol
- PROCYANIDIN B3
- CATECHIN-(4ALPHA->8)-CATECHIN
- CATECHIN-(4ALPHA->8)-CATECHIN B3
- (2R,2'R,3S,3'S,4S)-2,2'-Bis(3,4-dihydroxyphenyl)-4,8'-bichroman-3,3',5,5',7,7'-hexol
- (2R,2'R,3S,3'S,4α)-3,3',4,4'-Tetrahydro-2α,2'α-bis(3,4-dihydroxyphenyl)-4,8'-bi[2H-1-benzopyran]-3,3',5,5',7,7'-hexol
- CAS:
- 23567-23-9
- MF:
- C30H26O12
- MW:
- 578.52
- Product Categories:
-
- Catechins & Tannins
- Mol File:
- 23567-23-9.mol
PROCYANIDIN B3 Chemical Properties
- Melting point:
- 218-219℃
- Boiling point:
- 955.3±65.0 °C(Predicted)
- Density
- 1.705
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Soluble in acetone and acetonitrile
- form
- powder
- pka
- 9.29±0.60(Predicted)
- color
- White
- CAS DataBase Reference
- 23567-23-9
PROCYANIDIN B3 Usage And Synthesis
Uses
Procyanidin B3 is a natural product that acts as a specific HAT inhibitor. Procyanidin B3 is a polyphenol flavonoid dimer of (+)-catechin with diverse biological properties. Procyanidin B3 is a dimeric flavanol and an antifungal phenol extracted from Woodfordia uniflora.
Definition
ChEBI: A proanthocyanidin consisting of two molecules of (+)-catechin joined by a bond between positions 4 and 8' in alpha-configuration. It can be found in red wine, in barley, in beer, in peach or in Jatropha macrantha, the Huanarp Macho.
in vivo
Procyanidin B3 (100 mg/kg, p.o., 5 days a week for 4 weeks) prevents articular cartilage degeneration and heterotopic cartilage formation in a surgically-induced osteoarthritis mice model[2]. Procyanidin B3 (30 mg/kg, p.o., once daily for 4 weeks) delays the development of intervertebral disc degeneration (IVDD) in a Lipopolysaccharides (HY-D1056)-induced IVDD Sprague-Dawley rats model[2].
| Animal Model: | Lipopolysaccharides (HY-D1056)-induced IVDD (intervertebral disc degeneration) Sprague-Dawley rats model |
| Dosage: | 30 mg/kg |
| Administration: | Oral gavage (p.o.),once daily for 4 weeks |
| Result: | Prevented the loss of gelatin NP cells and structural damage of annulus fibrosus in IVDD rat model. |
| Animal Model: | Surgically-induced osteoarthritis mice model[2] |
| Dosage: | 100 mg/kg |
| Administration: | Oral gavage (p.o.), once daily, 5 days a week for 4 weeks |
| Result: | Prevented aberrant articular cartilage degeneration and heterotopic cartilage formation through suppression of the nitric oxide synthase (iNOS). |
IC 50
CBP/p300; TLR4
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PROCYANIDIN B3(23567-23-9)Related Product Information
- Procyanidin B1
- PROCYANIDIN A2
- PROCYANIDIN C1
- PROCYANIDIN B2(RG),(4→8)-Procyanidin B2,PROCYANIDIN B2
- (7S)-3,7,10,11-Tetrahydroxy-7,8-dihydro-6H-dibenzo[b,d]oxocin-7-methanol
- Prodelphinidin T4
- (4→6)-Procyanidin B5
- PROCYANIDIN A1
- PROCYANIDIN B-4
- N-BUTYLISOCYANIDE
- Tosylmethyl isocyanide
- SALCOMINE
- TERT-BUTYL ISOCYANIDE
- Benzyl isocyanide
- METHYL ISOCYANOACETATE
- TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
- Cupric acetylacetonate
- Ferric acetylacetonate