1,1,1-Trifluoroacetone Chemical Properties

Melting point:

-78 °C

Boiling point:

22 °C(lit.)

Density 

1.252 g/mL at 25 °C(lit.)

vapor pressure 

13.62 psi ( 20 °C)

refractive index 

n20/D 1.3(lit.)

Flash point:

−23 °F

storage temp. 

2-8°C

solubility 

Chloroform, Methanol

form 

Liquid

color 

Clear colorless

Water Solubility 

Miscible

Sensitive 

Lachrymatory

BRN 

1748614

Stability:

Volatile

InChIKey

FHUDAMLDXFJHJE-UHFFFAOYSA-N

CAS DataBase Reference

421-50-1(CAS DataBase Reference)

NIST Chemistry Reference

2-Propanone, 1,1,1-trifluoro-(421-50-1)

EPA Substance Registry System

2-Propanone, 1,1,1-trifluoro- (421-50-1)

Safety Information

Hazard Codes 

F+,Xi,F

Risk Statements 

12-36/37/38

Safety Statements 

16-26-29-33-36-7/9-9-37/39-39

RIDADR 

UN 1993 3/PG 1

WGK Germany 

3

F 

19

Hazard Note 

Flammable/Lachrymatory

TSCA 

T

HazardClass 

3

PackingGroup 

I

HS Code 

29147090

MSDS

• Language:English Provider:1,1,1-Trifluoro-2-propanone
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1,1,1-Trifluoroacetone Usage And Synthesis

Chemical Properties

1,1,1-Trifluoroacetone is CLEAR COLOURLESS LIQUID

Uses

1,1,1-Trifluoroacetone is used as intermediate of bioactive substance and antihypertensive drug, and as effective synthetic building block and trifluoromethyl reaction reagent.

Uses

1,1,1-Trifluoroacetone is a general chemical reagent used in the synthesis of glucokinase-glucokinase regulatory protein) GK-GKRP disruptors which may act as potential targets for type II diabetics. Reactant for enantioselective cycloadditions.

Uses

Used in a synthesis of 2-trifluoromethyl-7-azaindoles starting with 2,6-dihalopyridines. The derived chiral imine was used to prepare enantiopure α-trifluoromethyl alanines and diamines via a Strecker reaction followed by either nitrile hydrolysis or reduction.

1,1,1-Trifluoroacetone(421-50-1)Related Product Information

• Citric acid monohydrate
• Acetylacetone
• Calcium pyruvate
• Thenoyltrifluoroacetone
• Pyruvic acid
• Trifluoroacetic acid
• Triacetonamine
• 1,1,3-Trichloroacetone
• Trifluoroacetophenone
• Ethyl 4,4,4-trifluoroacetoacetate
• ZIRCONIUM TRIFLUOROACETYLACETONATE
• 4,4,4-Trifluoro-1-phenyl-1,3-butanedione
• 3-BROMO-1,1,1-TRIFLUOROACETONE,1-BROMO-3,3,3-TRIFLUOROACETONE 97%,1-BROMO-3,3,3-TRIFLUOROACETONE,3-Bromo-1,1,1-trifluoroacetone, min. 97%
• Propiophenone
• Phenylacetone
• METHYL TRIFLUOROPYRUVATE
• Ethyl trifluoropyruvate
• PALLADIUM(II) HEXAFLUOROACETYLACETONATE