H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH Chemical Properties

Boiling point:

1692.1±65.0 °C(Predicted)

Density 

1.48±0.1 g/cm3(Predicted)

storage temp. 

-15°C

solubility 

DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml

form 

A crystalline solid

pka

3.05±0.10(Predicted)

color 

White to off-white

Water Solubility 

water: 1mg/mL
5% acetic acid: 5mg/mL

Sequence

Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr (Disulfide bridge:Cys2-Cys8)

H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH Usage And Synthesis

Uses

WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. (This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.)

Biological Activity

Cell permeable: no', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 5 μM as TNF-α antagonist

References

[1] Lin CC, et al. Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFalpha. Biomaterials. 2009 Oct;30(28):4907-14. DOI:10.1016/j.biomaterials.2009.05.083

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