Methyltetrazine-PEG4-Amine Chemical Properties

Boiling point:

558.7±60.0 °C(Predicted)

Density 

1.186±0.06 g/cm3(Predicted)

solubility 

Soluble in Water, DMSO, DMF, DCM

pka

8.74±0.10(Predicted)

Methyltetrazine-PEG4-Amine Usage And Synthesis

Description

Methyltetrazine-PEG4-amine is an aqueous soluble PEGylation reagent containing a free amine and a methyltetrazine group. Methyl group improves the stability and hydrophilic PEG spacer increases water-solubility. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene).

Uses

Methyltetrazine-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Methyltetrazine-PEG4-Amine(1802908-05-9)Related Product Information

• Methyltetrazine-PEG4-Acid
• N-[2-[2-[2-[2-(Aminooxy)ethoxy]ethoxy]ethoxy]ethoxy]-4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzeneacetamide
• Me-Tet-PEG4-NH2
• Tetrazine-PEG4-amine HCl salt
• Methyltetrazine-propylamine HCl salt
• TAMRA-PEG4-Tetrazine
• Methyltetrazine-PEG4-Alkyne
• Methyltetrazine-PEG4-Azide
• Desthiobiotin-PEG4-Alkyne
• Tetrazine-PEG4-maleimide
• Dde Biotin-PEG4-Alkyne
• Methyltetrazine-PEG5-Alkyne
• Dde Biotin-PEG4-Azide
• Bis-sulfone-PEG3-Azide
• Methyltetrazine-PEG4-NHS Ester