SPHINGOMYELINASE Chemical Properties

storage temp. 

2-8°C

form 

lyophilized powder

color 

White to off-white

biological source

Staphylococcus aureus

Specific Activity

100-300units/mg protein (Lowry)

Safety Information

Hazard Codes 

B

Safety Statements 

23-24/25

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

SPHINGOMYELINASE Usage And Synthesis

Uses

sphingomyelinase is a fluid that can enhance the skin’s moistureretention properties.

Uses

Sphingomyelinase from Bacillus cereus has been used:

• in the measurement of membrane capacitance in brain slices
• for testing and confirming its silkworm-killing activity
• in enzyme activity assay and for elucidating its effect on hydrolysis of sphingomyelin in complex lipid mixtures

Uses

Sphingomyelinase from Staphylococcus aureus has been used to:

• induce neurotoxicity in rat cortical cultures to study the protective effects of minocycline
• determine the concentration of sphingomyelin from serum samples
• enhance sphingomyelinase activity to study PARK9-mediated exosome biogenesis

General Description

Sphingomyelinase from Bacillus cereus (Bc-Smase) is a Mg²⁺-containing metalloenzyme. Bacillus cereus sphingomyelinase induces hemolysis of sheep erythrocytes.

Biochem/physiol Actions

Initiates the formation of sphingomyelin-based second messengers. Activates MAPK (mitogen-activated protein kinase) and SAPKs (stress-activated protein kinases); generates ceramide from sphingomyelin.

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