THIOFLAVINE S Chemical Properties

storage temp. 

Amber Vial, -20°C Freezer, Under inert atmosphere

solubility 

ethanol: water (1:1): soluble1mg/mL

form 

powder

Colour Index 

49010

color 

Dark Red to Very Dark Brown

Stability:

Light Sensitive

EPA Substance Registry System

C.I. Direct Yellow 7 (1326-12-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

THIOFLAVINE S Usage And Synthesis

Uses

Thioflavine S is a reagent also known as Direct Yellow 7; potentially useful as an amyloid plaque stain. Dyes and metabolites.

Definition

ChEBI: Thioflavine T is an organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo. It has a role as a fluorochrome, a histological dye and a geroprotector. It contains a thioflavin T cation.

Preparation

(a) primrose spirit alkali (C.I.Direct Yellow 59, C.I. 49000) methylation, then will be preparing sulphonated product (GP 1251738); (b) primrose spirit alkali stlfonation, then will product methylation (GP 53333).

Properties and Applications

green light yellow. For golden is soluble in water, but soluble in ethanol as a green fluorescent yellow. The strong sulfuric acid in nearly colorless, with blue fluorescence, after diluted orange yellow precipitation. Used for cellulose fiber, wool, silk dyeing, silk printing, also can be used for leather color. Exhaust dyeing, good levelness.

THIOFLAVINE S(1326-12-1)Related Product Information

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