EC 4.2.1.2 Chemical Properties

storage temp. 

2-8°C

form 

ammonium sulfate suspension

EPA Substance Registry System

Hydratase, fumarate (9032-88-6)

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

EC 4.2.1.2 Usage And Synthesis

Uses

Fumarase from porcine heart has been used:

• as a positive control in isocitrate dehydrogenase and α-ketoglutarate dehydrogenase assay
• for immobilized enzyme based stability assay
• in fumarate hydratase assays in human lung carcinoma cells (A549)

Definition

An enzyme that catalyzes the interconversion of fumaric acid and malic acid. It is an important reactant in the tricarboxylic acid cycle.

General Description

Fumarase (FH in human) is a well-known tricarboxylic-acid-cycle enzyme found in both the cytoplasm and mitochondria of all eukaryotes.

Biochem/physiol Actions

Fumarase catalyzes the reversible hydration of fumarate to malate. In its mitochondrial form, fumarate is involved in the Krebs Cycle, while the cytosolic form is involved in amino acid metabolism.

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