PLASMINOGEN
PLASMINOGEN Basic information
- Product Name:
- PLASMINOGEN
- Synonyms:
-
- PLASMINOGEN, GLU-TYPE, HUMAN
- PLASMINOGEN, GLU-TYPE, HUMAN PLASMA
- PLASMINOGEN, HUMAN
- PLASMINOGEN, HUMAN PLASMA
- PLASMA TRYPSINOGEN, HUMAN
- PROFIBRINOLYSIN
- PROFIBRINOLYSIN, HUMAN
- GLU-PLASMINOGEN (HUMAN)
- CAS:
- 9001-91-6
- MF:
- NULL
- MW:
- 0
- EINECS:
- 232-641-9
- Mol File:
- Mol File
PLASMINOGEN Chemical Properties
- storage temp.
- -20°C
- form
- lyophilized powder
- biological source
- human plasma
- Water Solubility
- water: soluble
- Specific Activity
- 7units/mg protein
MSDS
- Language:English Provider:SigmaAldrich
PLASMINOGEN Usage And Synthesis
Uses
Plasminogen is a single-chain glycoprotein found in human plasma and extracellular fluid. Certain activators, such as tissue plasminogen activator (tPA), convert plasminogen to its active form, plasmin. Plasminogen has been used to study its conversion into plasmin.
General Description
The plasminogen (PLG) gene is mapped to human chromosome 6q26. Plasminogen protein has a molecular weight of ?90kDa. It is composed of Pan-apple domain at the N-terminal, five kringle domains and serine protease domain at its C-terminal.
Biochem/physiol Actions
Plasminogen is the inactive precursor of the protease plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration. Plasmin cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. It is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).
PLASMINOGENSupplier
- Tel
- 86-21-63210123
- sj_scrc@sinopharm.com
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Tel
- 13672434928
- 3307355104@qq.com
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Tel
- 021-54721350 13524668266
- 2881505714@qq.com
PLASMINOGEN(9001-91-6)Related Product Information
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