4-(Trifluoromethyl)benzaldehyde Chemical Properties

Melting point:

1-2°C

Boiling point:

66-67 °C13 mm Hg(lit.)

Density 

1.275 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.463(lit.)

Flash point:

150 °F

storage temp. 

Inert atmosphere,2-8°C

solubility 

1.5g/l

form 

Liquid

Specific Gravity

1.275

color 

Clear colorless to yellow

Water Solubility 

Soluble in water. 1.5 g/L at 20°C

Sensitive 

Air Sensitive

BRN 

1101680

InChI

1S/C8H5F3O/c9-8(10,11)7-3-1-6(5-12)2-4-7/h1-5H

InChIKey

BEOBZEOPTQQELP-UHFFFAOYSA-N

SMILES

[H]C(=O)c1ccc(cc1)C(F)(F)F

CAS DataBase Reference

455-19-6(CAS DataBase Reference)

NIST Chemistry Reference

p-CF3C6H4CHO(455-19-6)

EPA Substance Registry System

Benzaldehyde, 4-(trifluoromethyl)- (455-19-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

10-23

Hazard Note 

Irritant

TSCA 

TSCA listed

HazardClass 

IRRITANT, AIR SENSITIVE

HS Code 

29130000

Storage Class

10 - Combustible liquids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2

MSDS

• Language:English Provider:4-(Trifluoromethyl)benzaldehyde
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-(Trifluoromethyl)benzaldehyde Usage And Synthesis

Chemical Properties

Clear colorless to yellow liquid

Uses

4-(Trifluoromethyl)benzaldehyde is a reactant that has been used in the preparation of N,N''-(Arylmethylene)bisamides with cytotoxic activity as anti cancer agents.

Definition

ChEBI: 4-(trifluoromethyl)benzaldehyde is a member of benzaldehydes.

Synthesis

Using p-trifluoromethylaniline as raw material, p-trifluoromethylbenzaldehyde was produced by diazotization, oxidization and hydrolysis, with a yield of 35.9%
The mixture of halogenated hydrocarbon additives and p-trifluoromethylchlorobenzene was slowly added to tetrahydrofuran solution impregnated with magnesium chips to synthesize Grignard reagent for p-trifluoromethylchlorobenzene; N,N-dimethylformamide was added to the above Grignard reagent for p-trifluoromethylchlorobenzene to obtain the product by reaction.

4-(Trifluoromethyl)benzaldehyde(455-19-6)Related Product Information

• 4-(Trifluoromethoxy)benzaldehyde
• Benzaldehyde
• 4-Trifluoromethylphenylboronic acid
• 4-(Trifluoromethyl)benzoic acid
• 2-(Trifluoromethyl)benzoic acid
• 4-Trifluoromethylphenol
• 3-(Trifluoromethyl)benzaldehyde
• p-Tolualdehyde
• Trifluoro-p-tolunitrile
• Trifluoromethanesulfonic acid
• 2-Methylbenzotrifluoride
• 4-(Trifluoromethyl)cinnamic acid
• 2-Aminobenzotrifluoride
• 4-(Trifluoromethyl)benzene-1-sulfonyl chloride
• Diethylstilbestrol
• 4'-(Trifluoromethyl)acetophenone
• p-Trifluoromethoxy phenol
• 4-(Trifluoromethylthio)phenol