DL-tert-Leucine Chemical Properties

Melting point:

>300 °C (lit.)

Boiling point:

242.49°C (rough estimate)

Density 

1.0975 (rough estimate)

refractive index 

1.4240 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

H₂O: 0.1 g/mL, clear, colorless

pka

2.39±0.12(Predicted)

form 

Solid

color 

White to off-white

Water Solubility 

soluble

BRN 

1721823

InChI

InChI=1S/C6H13NO2/c1-6(2,3)4(7)5(8)9/h4H,7H2,1-3H3,(H,8,9)

InChIKey

NPDBDJFLKKQMCM-UHFFFAOYSA-N

SMILES

C(O)(=O)C(C(C)(C)C)N

CAS DataBase Reference

33105-81-6(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

29224995

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

DL-tert-Leucine Usage And Synthesis

Chemical Properties

white powder

Uses

peptide synthesis

Definition

ChEBI: Tert-butylglycine is a glycine derivative that is glycine with a tertiary butyl group at position 2. It has a role as a metabolite.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

The general procedure for synthesizing DL-tert-leucine from D-tert-leucine is as follows: Example 3A: A 30% ammonium hydroxide solution (50 mL) was added to the autoclave, followed by D-tert-leucine (5 g). The autoclave was sealed and the mixture was heated to 85°C under stirring conditions and maintained at this temperature for 12 hours of reaction. Upon completion of the reaction, the reaction mixture was cooled and the solution was transferred to a rotary evaporator and concentrated under vacuum at 55 °C. The solid residue obtained after concentration was mixed with acetone (20 mL) with stirring, followed by filtration and drying to finally obtain DL-tert-leucine (4.6 g, 92% yield, of which the L-isomer accounted for 42% and the D-isomer for 58%).

References

[1] Patent: US2012/245379, 2012, A1. Location in patent: Page/Page column 3
[2] Patent: EP2502896, 2012, A1. Location in patent: Page/Page column 4-5

DL-tert-Leucine(33105-81-6)Related Product Information

• 6-Aminocaproic acid
• N-CARBOBENZOXY-DL-LEUCINE
• Methyl 4-tert-butylbenzoate
• Diethylstilbestrol
• tert-Butanol
• Glycine
• tert-Butyl methyl ether
• L-Leucine
• 4-tert-Butylcatechol
• ALTRENOGEST
• L-tert-Leucine
• tert-Butyl hydroperoxide
• tert-Butylbenzene
• tert-Butyldimethylsilyl chloride
• 2-tert-Butylphenol
• D-tert-Butylglycine
• Tris(hydroxymethyl)aminomethane
• DL-Leucine