DIPHTHERIA TOXIN Chemical Properties

storage temp. 

2-8°C

solubility 

Water: soluble

form 

lyophilized powder

Safety Information

Hazard Codes 

T+

Risk Statements 

28

Safety Statements 

22-24/25-45-36/37-28

RIDADR 

3172

WGK Germany 

3

RTECS 

XW5807200

HazardClass 

6.1(a)

PackingGroup 

I

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich

DIPHTHERIA TOXIN Usage And Synthesis

Uses

Diphtheria Toxin, CRM Mutant is an agent that does not have NAD:EF2 ADP-ribosyltransferase activity.

Uses

Diphtheria toxin may be used as a toxin element in the construction of immunotoxin for cell specific cytotoxicity. The translocation domain of bacterial toxins with natural endosome escape mechanism has been used in the development of efficient nonviral vectors for applications in gene therapy.

Biochem/physiol Actions

Inhibits protein synthesis by catalyzing ADP-ribosylation of eukaryotic aminoacyltransferase II.

References

[1] LADOKHIN A S. pH-triggered conformational switching along the membrane insertion pathway of the diphtheria toxin T-domain.[J]. Toxins, 2013, 5 8: 1362-1380. DOI: 10.3390/toxins5081362
[2] MURPHY J R. Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process.[J]. Toxins, 2011, 3 3: 294-308. DOI: 10.3390/toxins3030294
[3] MAREIKE BÜTEPAGE. Intracellular Mono-ADP-Ribosylation in Signaling and Disease.[J]. Cells, 2015, 4 4: 569-595. DOI: 10.3390/cells4040569

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