ML224
ML224 Basic information
- Product Name:
- ML224
- Synonyms:
-
- ML224
- ANTAG3)
- ML224(NCGC00242364
- CS-1585
- NCGC00242364
- NCGC00242364;ANTAG3;ML-224;ML 224
- ML-224(ANTAG3)
- Acetamide, N-[4-[[5-[3-(2-furanylmethyl)-1,2,3,4-tetrahydro-4-oxo-2-quinazolinyl]-2-methoxyphenyl]methoxy]-3,5-dimethylphenyl]-
- CAS:
- 1338824-21-7
- MF:
- C31H31N3O5
- MW:
- 525.59
- Mol File:
- 1338824-21-7.mol
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ML224 Chemical Properties
- Boiling point:
- 752.3±60.0 °C(Predicted)
- Density
- 1.252±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (190.26 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- Powder
- pka
- 14.52±0.70(Predicted)
- color
- White to off-white
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ML224 Usage And Synthesis
Uses
ML224 (NCGC00242364) is a selective TSHR antagonist with an IC50 value of 2.1 μM. ML224 can be used in the study of Graves' disease and other thyroid disorders.
Definition
ChEBI: N-[4-[[5-[3-(2-furanylmethyl)-4-oxo-1,2-dihydroquinazolin-2-yl]-2-methoxyphenyl]methoxy]-3,5-dimethylphenyl]acetamide is a member of quinazolines.
in vivo
ANTAG3 (2 mg/mice; i.p. via osmotic pump; single daily for 3 days) lowers serum FT4 levels and thyroidal mRNAs for TPO and NIS in mice continuously stimulated by TRH[1].
| Animal Model: | Female BALB/c mice (8 to 13-week-old; ~18.7 g)[1]. |
| Dosage: | 2 mg/mice |
| Administration: | Intraperitoneal injection via osmotic pump; single daily for 3 days |
| Result: | Lowered the levels of FT4 by 44%, and the levels of TPO and NIS mRNAs by 75% and 83%, respectively. |
IC 50
TSHR: 2.1 μM (IC50); LHR: ＞30 μM (IC50); FSHR: ＞30 μM (IC50)
References
[1] Neumann S, et al. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan;155(1):310-4. DOI:10.1210/en.2013-1835
ML224Supplier
Haoyuan Chemexpress Co., Ltd.
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- 021-58950125
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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- 028-81700200 18116577057
- 3003855609@qq.com
LETOPHARM LIMITED
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- +86-21-5821 5861
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Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
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