CID-49830258 Chemical Properties

Boiling point:

696.6±65.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: soluble5mg/mL, clear (warmed)

form 

powder

pka

4.53±0.10(Predicted)

color 

white to yellow to light brown

Safety Information

WGK Germany 

3

CID-49830258 Usage And Synthesis

Uses

ML 240 is a p97 inhibitor in cancer and neurodegenerative diseases.

Uses

ML240 has been used as an inhibitor of D2 ATPase activity of valosin-containing protein.

Definition

ChEBI: ML240 is a member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP). It has a role as an antineoplastic agent. It is a member of quinazolines, a member of benzimidazoles, a secondary amino compound, an aromatic amine, an aromatic ether and a primary amino compound.

Biochem/physiol Actions

ML240 is a selective, ATP-competetive inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). The IC50 for p97 inhibition is 110 nM. ML240 rapidly induces activity of Caspases 3 and 7, leading to apoptosis. ML240 has potent antiproliferative activity towards NCI-60 cancer cell lines.

storage

Store at +4°C

CID-49830258(1346527-98-7)Related Product Information

• 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
• ML-228
• ML188 (Racemate)
• ML 18
• ML-098
• ML277
• ML 204
• ML329
• ML364
• VU0456810
• ML188
• ML418
• [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
• ML213
• N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
• ML-327
• PTP1B-IN-2
• ML264