2'-O-MOE-A(Bz)-3'-phosphoramidite Chemical Properties

pka

7.87±0.43(Predicted)

form 

Solid

color 

White to off-white

InChI

InChI=1/C50H58N7O9P/c1-34(2)57(35(3)4)67(64-28-14-27-51)66-44-42(31-63-50(37-17-12-9-13-18-37,38-19-23-40(60-6)24-20-38)39-21-25-41(61-7)26-22-39)65-49(45(44)62-30-29-59-5)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-15-10-8-11-16-36/h8-13,15-26,32-35,42,44-45,49H,14,28-31H2,1-7H3,(H,52,53,55,58)/t42-,44-,45-,49-,67?/s3

InChIKey

VPBYBQBHLYRLHG-VCCSSPGHNA-N

SMILES

O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](OCCOC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,46,52,r|

2'-O-MOE-A(Bz)-3'-phosphoramidite Usage And Synthesis

Description

2'-O-MOE-A(Bz)-3'-phosphoramidite, also known as DMT-2'-O-MOE-rA(Bz) phosphoramidite, inserts 2'-O-methoxyethyl-modified adenosine into oligonucleotide phosphoramidites for antisense RNA. Its 2'-MOE backbone bolsters duplex stability, nuclease resistance, and has low toxicity, contributing to effective, safe genetic manipulation. It is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).

Chemical Properties

The IUPAC name of 2'-O-MOE-A(Bz)-3'-phosphoramidite is (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite. It is white to off-white powder.

Uses

N6-Benzoyl-5''-O-DMT-2''-O-(2-methoxyethyl)adenosine 3''-CE phosphoramidite (CAS# 251647-53-7) is used diagnostically in the screening of insulin-like growth factor-I (IGF-I) and growth hormone receptor (GHR) oligonucleotidic modulators.

2'-O-MOE-A(Bz)-3'-phosphoramidite(251647-53-7)Related Product Information

• 2'-O-Methylcytidine
• DMT-2μ-O-Me-rG(ib) amidite
• 2’-O-Methyl-rA(N-Bz)phosphoramidite
• DMT-2′Fluoro-dU Phosphoramidite
• 2'-O-(2-Methoxyethyl)-5-methyluridine
• N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite
• N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine 3'-CE phosphoramidite
• Dmt-2'-f-dc(ac) amidite
• 2'-O-Methyladenosine
• 2'-O-(2-Methoxyethyl)cytidine
• 2'-O-Methylguanosine
• 2'-O-(2-Methoxyethyl)uridine
• DMT-2'-O-MOE-rU Phosphoramidite
• 2'-O-MOE-ADENOSINE
• 2'-OMe-ibu-G Phosphoramidite
• 2'-O-(2-Methoxyethyl)guanosine