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(+/-)4-HDOHE

Basic information Safety Supplier Related

(+/-)4-HDOHE Basic information

Product Name:
(+/-)4-HDOHE
Synonyms:
  • 4-HYDROXY DOCOSAHEXAENOIC ACID
  • (+/-)4-HDOHE
  • (+/-)4-HYDROXY-5E,7Z,10Z,13Z,16Z,19Z-DOCOSAHEXAENOIC ACID
  • (±)4-HDHA
  • IFRKCNPQVIJFAQ-PQVBWYSWSA-N
  • 5,7,10,13,16,19-Docosahexaenoic acid, 4-hydroxy-, (5E,7Z,10Z,13Z,16Z,19Z)-
  • (+/-)4-HDOHE
CAS:
90906-40-4
MF:
C22H32O3
MW:
344.49
Mol File:
90906-40-4.mol
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(+/-)4-HDOHE Chemical Properties

Boiling point:
502.3±50.0 °C(Predicted)
Density 
0.995±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
pka
4.57±0.10(Predicted)
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(+/-)4-HDOHE Usage And Synthesis

Description

(±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells also produces 4-HDHA. However, the enzymatic product is most likely the S-isomer. (±)4-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

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