Kavain Chemical Properties

Melting point:

142-148 °C

Boiling point:

432.6±45.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

Amber Vial, -20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Solid

color 

Off-White to Pale Yellow

BRN 

177877

Stability:

Light and Moisture Sensitive

InChI

InChI=1S/C14H14O3/c1-16-13-9-12(17-14(15)10-13)8-7-11-5-3-2-4-6-11/h2-8,10,12H,9H2,1H3/b8-7+

InChIKey

XEAQIWGXBXCYFX-BQYQJAHWSA-N

SMILES

C1(=O)OC(/C=C/C2=CC=CC=C2)CC(OC)=C1

LogP

1.690 (est)

CAS DataBase Reference

3155-48-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

F 

10-23

MSDS

• Language:English Provider:SigmaAldrich

Kavain Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Kava Piper methysticum.

Uses

anticonvulsant, analgesic, anxiolytic, suppreses excitatory postsynaptic potential

Uses

rac-Kavain is the main kavalactone found in the roots of the kava plant. Kavain is known to exhibit anticonvulsive properties by attenuating vascular smooth muscle contraction through interactions with voltage-dependent sodium and calcium channels. rac-Kavain was shown in recent research to exhibit protective properties on anaerobic glycolysis, ATP content and intracellular calcium and sodium of anoxic brain vesicles.

Definition

ChEBI: DL-kavain is /ProductChemicalPropertiesCB9738874_EN.htm It has a role as a glycine receptor antagonist.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 4070, 1976 DOI: 10.1021/jo00888a004

Kavain(3155-48-4)Related Product Information

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