Kavain Chemical Properties

Melting point:

142-148 °C

Boiling point:

432.6±45.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

Amber Vial, -20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Solid

color 

Off-White to Pale Yellow

BRN 

177877

Stability:

Light and Moisture Sensitive

InChI

InChI=1S/C14H14O3/c1-16-13-9-12(17-14(15)10-13)8-7-11-5-3-2-4-6-11/h2-8,10,12H,9H2,1H3/b8-7+

InChIKey

XEAQIWGXBXCYFX-BQYQJAHWSA-N

SMILES

C1(=O)OC(/C=C/C2=CC=CC=C2)CC(OC)=C1

LogP

1.690 (est)

CAS DataBase Reference

3155-48-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

F 

10-23

MSDS

• Language:English Provider:SigmaAldrich

Kavain Usage And Synthesis

Uses

anticonvulsant, analgesic, anxiolytic, suppreses excitatory postsynaptic potential

Uses

rac-Kavain is the main kavalactone found in the roots of the kava plant. Kavain is known to exhibit anticonvulsive properties by attenuating vascular smooth muscle contraction through interactions with voltage-dependent sodium and calcium channels. rac-Kavain was shown in recent research to exhibit protective properties on anaerobic glycolysis, ATP content and intracellular calcium and sodium of anoxic brain vesicles.

Definition

ChEBI: DL-kavain is /ProductChemicalPropertiesCB9738874_EN.htm It has a role as a glycine receptor antagonist.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 4070, 1976 DOI: 10.1021/jo00888a004

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