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Trifluoroacetamide

Product Name
Trifluoroacetamide
CAS No.
354-38-1
Chemical Name
Trifluoroacetamide
Synonyms
2,2,2-TRIFLUOROACETAMIDE;Acetamide, 2,2,2-trifluoro-;CF3CONH2;Triflouroacetamide;Three-;TRIFLUOROACETAMIDE;2-TriflouroacetaMide;Three fluoroacetaMide;Trifluoroacetamide98%;2,2,2-Trifluoracetamid
CBNumber
CB0291820
Molecular Formula
C2H2F3NO
Formula Weight
113.04
MOL File
354-38-1.mol
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Trifluoroacetamide Property

Melting point:
65-70 °C (lit.)
Boiling point:
162.5 °C (lit.)
Density 
1.4176 (estimate)
Flash point:
162-164°C
storage temp. 
Store below +30°C.
solubility 
460 g/L (20°C)
pka
12.33±0.50(Predicted)
form 
Crystalline Powder or Crystals
color 
White to pale yellow or beige
PH
3.6 (460g/l, H2O, 23℃)
Water Solubility 
460 g/L (20 ºC)
BRN 
1753625
InChIKey
NRKYWOKHZRQRJR-UHFFFAOYSA-N
LogP
0.725 at 23℃ and pH4.83
Dissociation constant
0 at 23℃
CAS DataBase Reference
354-38-1(CAS DataBase Reference)
NIST Chemistry Reference
Acetamide, 2,2,2-trifluoro-(354-38-1)
EPA Substance Registry System
Acetamide, 2,2,2-trifluoro- (354-38-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
RIDADR 
1759
WGK Germany 
3
Hazard Note 
Harmful/Irritant
TSCA 
T
HazardClass 
8
PackingGroup 
III
HS Code 
29241900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.14690
Product name
2,2,2-Trifluoroacetamide
Purity
for synthesis
Packaging
10G
Price
$37
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14690
Product name
2,2,2-Trifluoroacetamide
Purity
for synthesis
Packaging
50G
Price
$128
Updated
2024/03/01
Sigma-Aldrich
Product number
144657
Product name
Trifluoroacetamide
Purity
97%
Packaging
25g
Price
$42.1
Updated
2024/03/01
Sigma-Aldrich
Product number
144657
Product name
Trifluoroacetamide
Purity
97%
Packaging
100g
Price
$111
Updated
2024/03/01
TCI Chemical
Product number
T0598
Product name
Trifluoroacetamide
Purity
>98.0%(GC)
Packaging
25g
Price
$20
Updated
2024/03/01
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Trifluoroacetamide Chemical Properties,Usage,Production

Chemical Properties

white to pale yellow or beige crystalline powder

Uses

2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.

Application

Trifluoroacetamide was used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies.

Preparation

One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.
10.1142/S1088424621500292

General Description

Trifluoroacetamide is a good quencher of tryptophan fluorescence.

Trifluoroacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

5-(CHLOROMETHYL)-2-(TRIFLUOROMETHYL)THIAZOLE (2-(TRIFLUOROMETHYL)THIAZOL-5-YL)METHANOL 2-BROMO-1-(2-(TRIFLUOROMETHYL)THIAZOL-5-YL)ETHANONE ETHYL 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE 2,2,2-TRIFLUOROETHYLAMINE 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBALDEHYDE
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Trifluoroacetamide Suppliers

Austria 1 Belgium 2 China 359 Europe 4 France 1 Germany 7 India 19 Italy 1 Japan 6 Russia 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 16 United States 53 Global 475
Pure Chemistry Scientific Inc.
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View Lastest Price from Trifluoroacetamide manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Trifluoroacetamide 354-38-1
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-29
Hebei Chuanghai Biotechnology Co,.LTD
Product
Trifluoroacetamide 354-38-1
Price
US $20.60/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000kg
Release date
2024-08-21
Shaanxi Dideu Medichem Co. Ltd
Product
Trifluoroacetamide 354-38-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20t
Release date
2024-06-11

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