SU 4312

ChemicalBook > CAS DataBase List > SU 4312

Product Name: SU 4312
CAS No.: 5812-07-7
Chemical Name: SU 4312
Synonyms: SU 4312;NSC 86429;SU4312(NSC86429);SU 4312;NSC 86429;SU-4312;NSC-86429;3-(4-DIMETHYLAMINOBENZYLIDENYL)-2-INDOLINONE;(Z)-3-(4-(DIMETHYLAMINO)BENZYLIDENE)INDOLIN-2-ONE;SU4312, VEGFR and PDGFR receptor tyrosine kinase inhibitor;3-[[(4-DIMETHYLAMINO)PHENYL]METHYLENE]-1,3-DIHYDRO-2H-INDOL-2-ONE;2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro;3-[[(4-Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture
CBNumber: CB0444460
Molecular Formula: C17H16N2O
Formula Weight: 264.32
MOL File: 5812-07-7.mol

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SU 4312 Property

Melting point:: 225-232 °C
Boiling point:: 497.1±45.0 °C(Predicted)
Density: 1.219±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 30 mg/mL
form: Orange solid.
pka: 12.89±0.20(Predicted)
color: orange
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S8567
Product name: SU 4312
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 20213
Product name: SU 4312
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20213
Product name: SU 4312
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 20213
Product name: SU 4312
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 20213
Product name: SU 4312
Purity: ≥98%
Packaging: 25mg
Price: $305
Updated: 2024/03/01

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SU 4312 Chemical Properties,Usage,Production

Description

SU-4312 (5812-07-7) is a potent selective inhibitor of VEGFR kinase (also known as Flk-1 and KDR). Inhibition of the activated kinase (IC50 = 0.4 μM) is 100-fold less than inhibition of the unactivated kinase (IC50 = 0.04 μM). SU-4312 also inhibits PDGFR kinase (IC50 = 19.4 μM).

Uses

SU 4312 is a vascular endothelial growth factor receptor KDR tyrosine kinase antagonist.

Definition

ChEBI: A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein yrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.

Biological Activity

Potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC 50 values are 0.8 and 19.4 mM respectively). Selective over EGFR and c-Src tyrosine kinases.

References

1) Kendall et al. (1999), Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues; J. Biol. Chem., 274 6453 2) Sun et al. (1998), Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases; J. Med. Chem., 41 2588

SU 4312 Preparation Products And Raw materials

Raw materials

Preparation Products

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5812-07-7, SU 4312Related Search:

su5204 SU14813 SU5402 Geldanamycin Ko 143 S-Trityl-L-cysteine 17-AAG SU 5214 3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE SUN11602 SU 4942 SU 11274 SU 5205 (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide AAL-993 WAY-607500 CIVENTICHEM CV-409 MAZ51

3-[[(4-DIMETHYLAMINO)PHENYL]METHYLENE]-1,3-DIHYDRO-2H-INDOL-2-ONE

3-(4-DIMETHYLAMINOBENZYLIDENYL)-2-INDOLINONE

3-[[(4-Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture

NSC 86429

SU 4312

2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro

(Z)-3-(4-(DIMETHYLAMINO)BENZYLIDENE)INDOLIN-2-ONE

SU4312(NSC86429)

SU 4312;NSC 86429;SU-4312;NSC-86429

PDGFR,Inhibitor,SU4312,VEGFR,inhibit,Vascular endothelial growth factor receptor,Platelet-derived growth factor receptor,SU-4312

SU4312, VEGFR and PDGFR receptor tyrosine kinase inhibitor

5812-07-7

5812-7-7

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Receptor Tyrosine Kinase Inhibitors

Kinase/Phosphatase Biology

Vascular Endothelial Growth Factor Receptor and Platelet-Derived Growth Factor Receptor (VEGFR1/2 and PDGFR)

Protein Kinase

Angiogenesis and Metastasis