ChemicalBook > CAS DataBase List > SU 4312

SU 4312

Product Name
SU 4312
CAS No.
5812-07-7
Chemical Name
SU 4312
Synonyms
SU 4312;NSC 86429;SU4312(NSC86429);SU 4312;NSC 86429;SU-4312;NSC-86429;3-(4-DIMETHYLAMINOBENZYLIDENYL)-2-INDOLINONE;(Z)-3-(4-(DIMETHYLAMINO)BENZYLIDENE)INDOLIN-2-ONE;3-[[(4-DIMETHYLAMINO)PHENYL]METHYLENE]-1,3-DIHYDRO-2H-INDOL-2-ONE;2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro;3-[[(4-Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture;PDGFR,Inhibitor,SU4312,VEGFR,inhibit,Vascular endothelial growth factor receptor,Platelet-derived growth factor receptor,SU-4312
CBNumber
CB0444460
Molecular Formula
C17H16N2O
Formula Weight
264.32
MOL File
5812-07-7.mol
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SU 4312 Property

Melting point:
225-232 °C
Boiling point:
497.1±45.0 °C(Predicted)
Density 
1.219±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 30 mg/mL
form 
Orange solid.
pka
12.89±0.20(Predicted)
color 
orange
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S8567
Product name
SU 4312
Purity
≥98% (HPLC)
Packaging
5MG
Price
$142
Updated
2024/03/01
Cayman Chemical
Product number
20213
Product name
SU 4312
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20213
Product name
SU 4312
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
20213
Product name
SU 4312
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
20213
Product name
SU 4312
Purity
≥98%
Packaging
25mg
Price
$305
Updated
2024/03/01
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SU 4312 Chemical Properties,Usage,Production

Description

SU-4312 (5812-07-7) is a potent selective inhibitor of VEGFR kinase (also known as Flk-1 and KDR). Inhibition of the activated kinase (IC50 = 0.4 μM) is 100-fold less than inhibition of the unactivated kinase (IC50 = 0.04 μM). SU-4312 also inhibits PDGFR kinase (IC50 = 19.4 μM).

Uses

SU 4312 is a vascular endothelial growth factor receptor KDR tyrosine kinase antagonist.

Definition

ChEBI: A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein yrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.

Biological Activity

Potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC 50 values are 0.8 and 19.4 mM respectively). Selective over EGFR and c-Src tyrosine kinases.

References

1) Kendall et al. (1999), Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues; J. Biol. Chem., 274 6453 2) Sun et al. (1998), Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases; J. Med. Chem., 41 2588

SU 4312 Preparation Products And Raw materials

Raw materials

Preparation Products

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SU 4312 Suppliers

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5812-07-7, SU 4312Related Search:

su5204 SU14813 SU5402 Geldanamycin Ko 143 S-Trityl-L-cysteine 17-AAG SU 5214 3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE SUN11602 SU 4942 SU 11274 SU 5205 (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide AAL-993 WAY-607500 CIVENTICHEM CV-409 MAZ51

  • 3-[[(4-DIMETHYLAMINO)PHENYL]METHYLENE]-1,3-DIHYDRO-2H-INDOL-2-ONE
  • 3-(4-DIMETHYLAMINOBENZYLIDENYL)-2-INDOLINONE
  • 3-[[(4-Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture
  • NSC 86429
  • SU 4312
  • 2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro
  • (Z)-3-(4-(DIMETHYLAMINO)BENZYLIDENE)INDOLIN-2-ONE
  • SU4312(NSC86429)
  • SU 4312;NSC 86429;SU-4312;NSC-86429
  • PDGFR,Inhibitor,SU4312,VEGFR,inhibit,Vascular endothelial growth factor receptor,Platelet-derived growth factor receptor,SU-4312
  • 5812-07-7
  • 5812-7-7
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Receptor Tyrosine Kinase Inhibitors
  • Kinase/Phosphatase Biology
  • Vascular Endothelial Growth Factor Receptor and Platelet-Derived Growth Factor Receptor (VEGFR1/2 and PDGFR)
  • Protein Kinase
  • Angiogenesis and Metastasis