SU 4312
- Product Name
- SU 4312
- CAS No.
- 5812-07-7
- Chemical Name
- SU 4312
- Synonyms
- SU 4312;NSC 86429;SU4312(NSC86429);SU 4312;NSC 86429;SU-4312;NSC-86429;3-(4-DIMETHYLAMINOBENZYLIDENYL)-2-INDOLINONE;(Z)-3-(4-(DIMETHYLAMINO)BENZYLIDENE)INDOLIN-2-ONE;3-[[(4-DIMETHYLAMINO)PHENYL]METHYLENE]-1,3-DIHYDRO-2H-INDOL-2-ONE;2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro;3-[[(4-Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture;PDGFR,Inhibitor,SU4312,VEGFR,inhibit,Vascular endothelial growth factor receptor,Platelet-derived growth factor receptor,SU-4312
- CBNumber
- CB0444460
- Molecular Formula
- C17H16N2O
- Formula Weight
- 264.32
- MOL File
- 5812-07-7.mol
SU 4312 Property
- Melting point:
- 225-232 °C
- Boiling point:
- 497.1±45.0 °C(Predicted)
- Density
- 1.219±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 30 mg/mL
- form
- Orange solid.
- pka
- 12.89±0.20(Predicted)
- color
- orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S8567
- Product name
- SU 4312
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $142
- Updated
- 2024/03/01
- Product number
- 20213
- Product name
- SU 4312
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20213
- Product name
- SU 4312
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 20213
- Product name
- SU 4312
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 20213
- Product name
- SU 4312
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $305
- Updated
- 2024/03/01
SU 4312 Chemical Properties,Usage,Production
Description
SU-4312 (5812-07-7) is a potent selective inhibitor of VEGFR kinase (also known as Flk-1 and KDR). Inhibition of the activated kinase (IC50 = 0.4 μM) is 100-fold less than inhibition of the unactivated kinase (IC50 = 0.04 μM). SU-4312 also inhibits PDGFR kinase (IC50 = 19.4 μM).
Uses
SU 4312 is a vascular endothelial growth factor receptor KDR tyrosine kinase antagonist.
Definition
ChEBI: A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein yrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
Biological Activity
Potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC 50 values are 0.8 and 19.4 mM respectively). Selective over EGFR and c-Src tyrosine kinases.
References
1) Kendall et al. (1999), Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues; J. Biol. Chem., 274 6453 2) Sun et al. (1998), Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases; J. Med. Chem., 41 2588