ChemicalBook > CAS DataBase List > 2-Amino-5-methylpyridine

2-Amino-5-methylpyridine

Product Name
2-Amino-5-methylpyridine
CAS No.
1603-41-4
Chemical Name
2-Amino-5-methylpyridine
Synonyms
5-METHYLPYRIDIN-2-AMINE;NSC 1489;NSC 96444;AKOS 91156;6-amino-3-picolin;2-AMINO-5-PICOLINE;6-AMINO-3-PICOLINE;TIMTEC-BB SBB004353;2-Amino-5-methylpyri;3-Picoline, 6-amino-
CBNumber
CB0485858
Molecular Formula
C6H8N2
Formula Weight
108.14
MOL File
1603-41-4.mol
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2-Amino-5-methylpyridine Property

Melting point:
76-77 °C(lit.)
Boiling point:
227 °C(lit.)
Density 
227
vapor pressure 
3.706Pa at 25℃
refractive index 
1,524-1,528
Flash point:
118°C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
1000g/l
form 
Crystalline Powder, Crystals or Flakes
pka
pK1: 7.22(+1) (25°C)
color 
White to light yellow
Sensitive 
Hygroscopic
BRN 
107050
InChIKey
CMBSSVKZOPZBKW-UHFFFAOYSA-N
LogP
1.08
CAS DataBase Reference
1603-41-4(CAS DataBase Reference)
NIST Chemistry Reference
2-Pyridinamine, 5-methyl-(1603-41-4)
EPA Substance Registry System
6-Amino-3-picoline (1603-41-4)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
23/24/25-36/37/38-25
Safety Statements 
26-36/37/39-45-37/39-28A
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
TJ5141000
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333999
Toxicity
LD50 orl-rat: 200 mg/kg 85JCAE -,841,86
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A75684
Product name
2-Amino-5-methylpyridine
Purity
99%
Packaging
10g
Price
$30.12
Updated
2024/03/01
Sigma-Aldrich
Product number
A75684
Product name
2-Amino-5-methylpyridine
Purity
99%
Packaging
50g
Price
$58.32
Updated
2024/03/01
TCI Chemical
Product number
A0732
Product name
2-Amino-5-methylpyridine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$46
Updated
2024/03/01
TCI Chemical
Product number
A0732
Product name
2-Amino-5-methylpyridine
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$489
Updated
2024/03/01
Alfa Aesar
Product number
A13330
Product name
2-Amino-5-methylpyridine, 99%
Packaging
50g
Price
$70.65
Updated
2024/03/01
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2-Amino-5-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

light yellow crystalline flakes

Uses

Intermediate.

Uses

2-Amino-5-methylpyridine is used as an intermediate in the pharmaceutical industry for the manufacture of Avosentan (used in diabetic nephropathy), Pirfenidone (anti-inflammatory, anti-oxidant and antifibrotic agent) and Zolpidem (sedative/ hypnotics). It is also used for the manufacture of Fluazuron, which is a pesticide, and for commercial purposes.

Safety Profile

Poison by ingestion,subcutaneous, and skin contact routes. When heated todecomposition it emits toxic vapors of NOx.

Synthesis

2.2 g (0.377 mol) of trimethylamine are condensed at -10 °C. and added at -5 °C. to a solution of 10.03 g (0.092 mol) of 3-methyl-pyridine 1-oxide in 120 ml of methylene chloride. At this temperature, 7.9 (0.11 mol) of thionyl chloride in 15 ml of methylene chloride is added dropwise in 30 minutes. The temperature during this process is kept below 0 °C. The resulting yellow solution is allowed to thaw and is stirred overnight at room temperature. The solvent is removed in vacuo 35 ml of a 48% strength hydrogen bromide solution and then added. The water is distilled off, and the mixture is then heated to 210 °C. A 48% strength hydrogen bromide solution is continuously added dropwise, and water is distilled. After 8 hours, the reaction is completed according to thin-layer chromatography. The mixture is allowed to cool and is adjusted to pH 9 using a dilute sodium hydroxide solution. The mixture is then extracted four times using ethyl acetate. After filtration, the combined extracts are dried over sodium sulphate and concentrated on the rotary evaporator. 8 g (80.5% of theory) of 2-amino-5-methylpyridine are obtained.

Purification Methods

Crystallise it from acetone. [Beilstein 22/9 V 289.]

2-Amino-5-methylpyridine Preparation Products And Raw materials

Raw materials

5-Methylpyridine Trimethylamine 3-Picoline-N-oxide Hydrogen bromide Trimethylamine hydrochloride Chloromethane

Preparation Products

6-(2,2,2-TRIFLUOROETHOXY)NICOTINIC ACID 2-Hydroxy-5-methyl-3-nitropyridine (6-AMINO-3-PYRIDINYL)METHANOL Ethyl 6-aminonicotinate Nalidixic acid 2-AMINO-3-NITRO-5-PICOLINE 6-Fluoronicotinic acid 2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID 3-AMINO-2-CHLORO-5-PICOLINE 2-Fluoro-5-methylpyridine TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL]CARBAMATE 6-AMINONICOTINOHYDRAZIDE 6-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID (5-METHOXYMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER Methyl 6-aminonicotinate METHYL 6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINATE 2,3-Dichloro-5-(trifluoromethyl)pyridine 2-Amino-3-bromo-5-methylpyridine 2-ACETYLAMINO-3-BROMO-5-METHYLPYRIDINE 2-ACETAMIDO-5-PICOLINE 2-BROMO-3-NITRO-5-METHYL PYRIDINE 2-Chloro-5-methylpyridine 2-Chloro-5-methyl-3-nitropyridine 6-Aminonicotinic acid 2-FLUOROPYRIDINE-5-CARBONYL CHLORIDE METHYL 6-(ACETYLAMINO)NICOTINATE
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2-Amino-5-methylpyridine Suppliers

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View Lastest Price from 2-Amino-5-methylpyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Amino-5-methylpyridine 1603-41-4
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
10 TONS
Release date
2021-06-24
Hebei Weibang Biotechnology Co., Ltd
Product
2-Amino-5-methylpyridine 1603-41-4
Price
US $19.00/ASSAYS
Min. Order
100ASSAYS
Purity
99%
Supply Ability
100 mt
Release date
2024-11-20
Shanghai Yongzeng Technology Co.,Ltd
Product
2-Amino-5-methylpyridine 1603-41-4
Price
US $0.00/gm
Min. Order
100gm
Purity
99%min
Supply Ability
100kgs
Release date
2024-09-04

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