2-Amino-5-methylpyridine
- Product Name
- 2-Amino-5-methylpyridine
- CAS No.
- 1603-41-4
- Chemical Name
- 2-Amino-5-methylpyridine
- Synonyms
- 5-METHYLPYRIDIN-2-AMINE;NSC 1489;NSC 96444;AKOS 91156;6-amino-3-picolin;2-AMINO-5-PICOLINE;6-AMINO-3-PICOLINE;TIMTEC-BB SBB004353;2-Amino-5-methylpyri;3-Picoline, 6-amino-
- CBNumber
- CB0485858
- Molecular Formula
- C6H8N2
- Formula Weight
- 108.14
- MOL File
- 1603-41-4.mol
2-Amino-5-methylpyridine Property
- Melting point:
- 76-77 °C(lit.)
- Boiling point:
- 227 °C(lit.)
- Density
- 227
- vapor pressure
- 3.706Pa at 25℃
- refractive index
- 1,524-1,528
- Flash point:
- 118°C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- 1000g/l
- form
- Crystalline Powder, Crystals or Flakes
- pka
- pK1: 7.22(+1) (25°C)
- color
- White to light yellow
- Sensitive
- Hygroscopic
- BRN
- 107050
- InChIKey
- CMBSSVKZOPZBKW-UHFFFAOYSA-N
- LogP
- 1.08
- CAS DataBase Reference
- 1603-41-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Pyridinamine, 5-methyl-(1603-41-4)
- EPA Substance Registry System
- 6-Amino-3-picoline (1603-41-4)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 23/24/25-36/37/38-25
- Safety Statements
- 26-36/37/39-45-37/39-28A
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- RTECS
- TJ5141000
- Hazard Note
- Irritant
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29333999
- Toxicity
- LD50 orl-rat: 200 mg/kg 85JCAE -,841,86
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A75684
- Product name
- 2-Amino-5-methylpyridine
- Purity
- 99%
- Packaging
- 10g
- Price
- $30.12
- Updated
- 2024/03/01
- Product number
- A75684
- Product name
- 2-Amino-5-methylpyridine
- Purity
- 99%
- Packaging
- 50g
- Price
- $58.32
- Updated
- 2024/03/01
- Product number
- A0732
- Product name
- 2-Amino-5-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $46
- Updated
- 2024/03/01
- Product number
- A0732
- Product name
- 2-Amino-5-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 500g
- Price
- $489
- Updated
- 2024/03/01
- Product number
- A13330
- Product name
- 2-Amino-5-methylpyridine, 99%
- Packaging
- 50g
- Price
- $70.65
- Updated
- 2024/03/01
2-Amino-5-methylpyridine Chemical Properties,Usage,Production
Chemical Properties
light yellow crystalline flakes
Uses
Intermediate.
Uses
2-Amino-5-methylpyridine is used as an intermediate in the pharmaceutical industry for the manufacture of Avosentan (used in diabetic nephropathy), Pirfenidone (anti-inflammatory, anti-oxidant and antifibrotic agent) and Zolpidem (sedative/ hypnotics). It is also used for the manufacture of Fluazuron, which is a pesticide, and for commercial purposes.
Safety Profile
Poison by ingestion,subcutaneous, and skin contact routes. When heated todecomposition it emits toxic vapors of NOx.
Synthesis
2.2 g (0.377 mol) of trimethylamine are condensed at -10 °C. and added at -5 °C. to a solution of 10.03 g (0.092 mol) of 3-methyl-pyridine 1-oxide in 120 ml of methylene chloride. At this temperature, 7.9 (0.11 mol) of thionyl chloride in 15 ml of methylene chloride is added dropwise in 30 minutes. The temperature during this process is kept below 0 °C. The resulting yellow solution is allowed to thaw and is stirred overnight at room temperature. The solvent is removed in vacuo 35 ml of a 48% strength hydrogen bromide solution and then added. The water is distilled off, and the mixture is then heated to 210 °C. A 48% strength hydrogen bromide solution is continuously added dropwise, and water is distilled. After 8 hours, the reaction is completed according to thin-layer chromatography. The mixture is allowed to cool and is adjusted to pH 9 using a dilute sodium hydroxide solution. The mixture is then extracted four times using ethyl acetate. After filtration, the combined extracts are dried over sodium sulphate and concentrated on the rotary evaporator. 8 g (80.5% of theory) of 2-amino-5-methylpyridine are obtained.
Purification Methods
Crystallise it from acetone. [Beilstein 22/9 V 289.]
2-Amino-5-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-5-methylpyridine Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
- Tel
- --
- Fax
- --
- reag-info@gms.kanto.co.jp
- Country
- Japan
- ProdList
- 6756
- Advantage
- 74
- Tel
- --
- Fax
- --
- labchem-tec@wako-chem.co.jp
- Country
- Japan
- ProdList
- 6819
- Advantage
- 80
View Lastest Price from 2-Amino-5-methylpyridine manufacturers
- Product
- 2-Amino-5-methylpyridine 1603-41-4
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 10 TONS
- Release date
- 2021-06-24
- Product
- 2-Amino-5-methylpyridine 1603-41-4
- Price
- US $19.00/ASSAYS
- Min. Order
- 100ASSAYS
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-20
- Product
- 2-Amino-5-methylpyridine 1603-41-4
- Price
- US $0.00/gm
- Min. Order
- 100gm
- Purity
- 99%min
- Supply Ability
- 100kgs
- Release date
- 2024-09-04