ChemicalBook > CAS DataBase List > 1-N-BOC-4-BROMOPIPERIDINE

1-N-BOC-4-BROMOPIPERIDINE

Product Name: 1-N-BOC-4-BROMOPIPERIDINE
CAS No.: 180695-79-8
Chemical Name: 1-N-BOC-4-BROMOPIPERIDINE
Synonyms: 1-Boc-4-bromopiperidine;1-Boc-4-broMopiperidin;4-BroMo-N-Boc-piperidine;N-BOC-4-BROMO-PIPERIDINE;1-N-BOC-4-BROMOPIPERIDINE;4-Bromo-2,22-diaminopyridine;1-tert-Butoxycarbonyl-4-bromopiperidine;ert-butyl4-bromopiperidine-1-carboxylate;tert-Butyl 4-bromo-1-piperidinecarboxylate;tert-Butyl 4-bromopiperidine-1-carboxylate
CBNumber: CB1127607
Molecular Formula: C10H18BrNO2
Formula Weight: 264.16
MOL File: 180695-79-8.mol

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1-N-BOC-4-BROMOPIPERIDINE Property

Melting point:: 42 °C
Boiling point:: 100-118 °C/0.5 mmHg
Density: 1.3403 g/mL at 25 °C
refractive index: n20/D 1.4905
Flash point:: 110 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to lump
pka: -2.77±0.40(Predicted)
color: White to Light yellow
InChI: InChI=1S/C10H18BrNO2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7H2,1-3H3
InChIKey: KZBWIYHDNQHMET-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(Br)CC1
CAS DataBase Reference: 180695-79-8

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 61
RIDADR: UN 3082 9/PG 3
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 687448
Product name: 1-Boc-4-bromopiperidine
Purity: 97%
Packaging: 5g
Price: $95.64
Updated: 2025/07/31

TCI Chemical

Product number: B5585
Product name: 1-tert-Butoxycarbonyl-4-bromopiperidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: B5585
Product name: 1-tert-Butoxycarbonyl-4-bromopiperidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $183
Updated: 2025/07/31

TRC

Product number: B695110
Product name: tert-Butyl4-Bromopiperidine-1-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR962067
Product name: N-BOC-4-Bromopiperidine
Purity: 97%
Packaging: 1g
Price: $16
Updated: 2021/12/16

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1-N-BOC-4-BROMOPIPERIDINE Chemical Properties,Usage,Production

Uses

N-Boc-4-Bromopiperidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

24424-99-5

54288-70-9

180695-79-8

Step 1: Synthesis of tert-butyl 4-bromopiperidine-1-carboxylate To a 35 mL dichloromethane suspension containing 5 g (0.02 mol) of 4-bromopiperidine hydrobromide, 7.09 mL (0.04 mol) of N,N-diisopropylethylamine was added slowly and dropwise at 0 °C. The reaction mixture was stirred for 30 minutes and then continued with the dropwise addition of 6.67 g (0.031 mol) of di-tert-butyl dicarbonate to a 35 mL dichloromethane solution. The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the reaction mixture was washed sequentially with 1 M aqueous hydrochloric acid (2 x 30 mL) and brine (30 mL). The organic layer was separated, dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure to give 6.9 g of 4-bromopiperidine-1-carboxylic acid tert-butyl ester as a yellow oil in quantitative yield. The product was characterized by 1H NMR (250 MHz, chloroform-d): δ 1.46 (9H, s), 1.79-2.00 (2H, m), 2.00-2.16 (2H, m), 3.31 (2H, ddd, J = 13.67,7.73,3.73 Hz), 3.68 (2H, ddd, J = 13.55,6.85,3.65 Hz), 4.34 (1H, tt, J = 7.69,3.81 Hz).

References

[1] Patent: US2010/76029, 2010, A1. Location in patent: Page/Page column 42
[2] Patent: US2011/71196, 2011, A1. Location in patent: Page/Page column 22; 23
[3] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 311 - 321
[4] Journal of the American Chemical Society, 2016, vol. 138, # 24, p. 7520 - 7523
[5] Organic Letters, 2000, vol. 2, # 1, p. 6 - 10

1-N-BOC-4-BROMOPIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-N-BOC-4-BROMOPIPERIDINE manufacturers

ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD

Product: 1-Boc-4-bromopiperidine 180695-79-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5ton/month
Release date: 2023-12-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Boc-4-bromopiperidine 180695-79-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1-N-BOC-4-BROMOPIPERIDINE 180695-79-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 500kg
Release date: 2018-08-17

180695-79-8, 1-N-BOC-4-BROMOPIPERIDINERelated Search:

Tetramethrin Butyl benzoate tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Formic acid 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester 4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester 1-Boc-4-methanesulfonyloxypiperidine 1-Boc-4-methylpiperidine-4-carboxylic acid tert-Butyl 4-iodopyrazole-1-carboxylate 1-Boc-pyrazole-4-boronic acid pinacol ester N-BOC-piperidine-4-carboxylic acid N-Boc-piperidine-4-aldehyde tert-Butyl 3-bromopropylcarbamate 1-N-BOC-4-BROMOPIPERIDINE 1-N-BOC-3-BROMOPIPERIDINE,1-Boc-3-bromopiperidine 4-BROMO-N-METHYL PIPERIDINE N-Boc-trans-4-bromo-3-hydroxypipiridine

1-N-BOC-4-BROMOPIPERIDINE

N-BOC-4-BROMO-PIPERIDINE

1-Piperidinecarboxylic acid, 4-bromo-, 1,1-dimethylethyl ester

1-Boc-4-bromopiperidine

tert-Butyl 4-bromopiperidine-1-carboxylate

1-Boc-4-broMopiperidin

4-BroMo-N-Boc-piperidine

1-tert-Butoxycarbonyl-4-bromopiperidine

tert-butyl 3-allyl-3-hydroxyazetidine-94-carboxylate

4-Bromo-2,22-diaminopyridine

1,1-Dimethylethyl 4-bromo-1-piperidinecarboxylate

ert-butyl4-bromopiperidine-1-carboxylate

tert-Butyl 4-bromo-1-piperidinecarboxylate

180695-79-8

pharmacetical

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Piperidines

PiperidinesHeterocyclic Building Blocks