1-N-BOC-4-BROMOPIPERIDINE
- Product Name
- 1-N-BOC-4-BROMOPIPERIDINE
- CAS No.
- 180695-79-8
- Chemical Name
- 1-N-BOC-4-BROMOPIPERIDINE
- Synonyms
- 1-Boc-4-bromopiperidine;1-Boc-4-broMopiperidin;4-BroMo-N-Boc-piperidine;N-BOC-4-BROMO-PIPERIDINE;1-N-BOC-4-BROMOPIPERIDINE;4-Bromo-2,22-diaminopyridine;1-tert-Butoxycarbonyl-4-bromopiperidine;ert-butyl4-bromopiperidine-1-carboxylate;tert-Butyl 4-bromo-1-piperidinecarboxylate;tert-Butyl 4-bromopiperidine-1-carboxylate
- CBNumber
- CB1127607
- Molecular Formula
- C10H18BrNO2
- Formula Weight
- 264.16
- MOL File
- 180695-79-8.mol
1-N-BOC-4-BROMOPIPERIDINE Property
- Melting point:
- 42 °C
- Boiling point:
- 100-118 °C/0.5 mmHg
- Density
- 1.3403 g/mL at 25 °C
- refractive index
- n20/D 1.4905
- Flash point:
- 110 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to lump
- pka
- -2.77±0.40(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C10H18BrNO2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7H2,1-3H3
- InChIKey
- KZBWIYHDNQHMET-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(Br)CC1
- CAS DataBase Reference
- 180695-79-8
N-Bromosuccinimide Price
- Product number
- 687448
- Product name
- 1-Boc-4-bromopiperidine
- Purity
- 97%
- Packaging
- 5g
- Price
- $95.64
- Updated
- 2025/07/31
- Product number
- B5585
- Product name
- 1-tert-Butoxycarbonyl-4-bromopiperidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $46
- Updated
- 2025/07/31
- Product number
- B5585
- Product name
- 1-tert-Butoxycarbonyl-4-bromopiperidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $183
- Updated
- 2025/07/31
- Product number
- B695110
- Product name
- tert-Butyl4-Bromopiperidine-1-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR962067
- Product name
- N-BOC-4-Bromopiperidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
1-N-BOC-4-BROMOPIPERIDINE Chemical Properties,Usage,Production
Uses
N-Boc-4-Bromopiperidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Synthesis
24424-99-5
54288-70-9
180695-79-8
Step 1: Synthesis of tert-butyl 4-bromopiperidine-1-carboxylate To a 35 mL dichloromethane suspension containing 5 g (0.02 mol) of 4-bromopiperidine hydrobromide, 7.09 mL (0.04 mol) of N,N-diisopropylethylamine was added slowly and dropwise at 0 °C. The reaction mixture was stirred for 30 minutes and then continued with the dropwise addition of 6.67 g (0.031 mol) of di-tert-butyl dicarbonate to a 35 mL dichloromethane solution. The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the reaction mixture was washed sequentially with 1 M aqueous hydrochloric acid (2 x 30 mL) and brine (30 mL). The organic layer was separated, dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure to give 6.9 g of 4-bromopiperidine-1-carboxylic acid tert-butyl ester as a yellow oil in quantitative yield. The product was characterized by 1H NMR (250 MHz, chloroform-d): δ 1.46 (9H, s), 1.79-2.00 (2H, m), 2.00-2.16 (2H, m), 3.31 (2H, ddd, J = 13.67,7.73,3.73 Hz), 3.68 (2H, ddd, J = 13.55,6.85,3.65 Hz), 4.34 (1H, tt, J = 7.69,3.81 Hz).
References
[1] Patent: US2010/76029, 2010, A1. Location in patent: Page/Page column 42
[2] Patent: US2011/71196, 2011, A1. Location in patent: Page/Page column 22; 23
[3] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 311 - 321
[4] Journal of the American Chemical Society, 2016, vol. 138, # 24, p. 7520 - 7523
[5] Organic Letters, 2000, vol. 2, # 1, p. 6 - 10
1-N-BOC-4-BROMOPIPERIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
1-N-BOC-4-BROMOPIPERIDINE Suppliers
- Tel
- --
- Fax
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- Country
- Switzerland
- ProdList
- 6896
- Advantage
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View Lastest Price from 1-N-BOC-4-BROMOPIPERIDINE manufacturers
- Product
- 1-Boc-4-bromopiperidine 180695-79-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5ton/month
- Release date
- 2023-12-09
- Product
- 1-Boc-4-bromopiperidine 180695-79-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1-N-BOC-4-BROMOPIPERIDINE 180695-79-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 500kg
- Release date
- 2018-08-17