ChemicalBook > CAS DataBase List > PF-9366
PF-9366
- Product Name
- PF-9366
- CAS No.
- 72882-78-1
- Chemical Name
- PF-9366
- Synonyms
- CS-2703;PF-9366;PF 9366 NEW;PF-9366; PF 9366; PF9366;72882-78-1;PF-9366,inhibit,PF9366,PF 9366,Inhibitor;[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl-;2-(7-Chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine
- CBNumber
- CB13375661
- Molecular Formula
- C20H19ClN4
- Formula Weight
- 350.84
- MOL File
- 72882-78-1.mol
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PF-9366 Property
- Melting point:
- 182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 20 mg/ml).
- pka
- 8.75±0.28(Predicted)
- form
- solid
- color
- Beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 30782
- Product name
- PF-9366
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30782
- Product name
- PF-9366
- Packaging
- 25mg
- Price
- $317
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30782
- Product name
- PF-9366
- Packaging
- 10mg
- Price
- $152
- Updated
- 2024/03/01
TRC
- Product number
- P294108
- Product name
- PF-9366
- Packaging
- 10mg
- Price
- $825
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- BP164086
- Product name
- PF 9366 NEW
- Packaging
- 10mg
- Price
- $125
- Updated
- 2021/12/16
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PF-9366 Chemical Properties,Usage,Production
Description
PF-9366 (72882-78-1) is an allosteric inhibitor (IC50?= 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1?It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 μM and 225 nM respectively.
Uses
PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform.
References
1) Quinlan?et al. (2017),?Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A; Nat. Chem. Biol.,?13?785
PF-9366 Preparation Products And Raw materials
Raw materials
Preparation Products
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PF-9366 Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
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