PF-6274484

Product Name: PF-6274484
CAS No.: 1035638-91-5
Chemical Name: PF-6274484
Synonyms: PF-6274484;PF-6274484 >=98% (HPLC);PF-6274484, 10 mM in DMSO;N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)acrylamide;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide;2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-;oxidation,autophosphorylation,PF6274484,PF-6274484,EGFR,signaling,Epidermal growth factor receptor,HER1,protein,ErbB-1,inhibit,kinase,cysteine,Inhibitor
CBNumber: CB14666748
Molecular Formula: C18H14ClFN4O2
Formula Weight: 372.78
MOL File: 1035638-91-5.mol

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PF-6274484 Property

storage temp.: Store at -20°C
solubility: DMF: 33 mg/ml; DMSO: 25 mg/ml
form: A crystalline solid
color: Light yellow to orange

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22698
Product name: PF-6274484
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 22698
Product name: PF-6274484
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 22698
Product name: PF-6274484
Purity: ≥98%
Packaging: 10mg
Price: $166
Updated: 2024/03/01

TRC

Product number: P294153
Product name: PF6274484
Packaging: 50mg
Price: $820
Updated: 2021/12/16

AK Scientific

Product number: 8711DW
Product name: N-[4-(3-Chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide
Packaging: 5mg
Price: $209
Updated: 2021/12/16

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PF-6274484 Chemical Properties,Usage,Production

Description

PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.

PF-6274484 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-6274484 Suppliers

China 20 United Kingdom 1 United States 3 USA 1 Global 25

Shanghai EFE Biological Technology Co., Ltd.

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Neobioscience Co., Ltd.

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Proteintech China

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1035638-91-5, PF-6274484Related Search:

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PF-6274484

N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide

2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-

PF-6274484 >=98% (HPLC)

oxidation,autophosphorylation,PF6274484,PF-6274484,EGFR,signaling,Epidermal growth factor receptor,HER1,protein,ErbB-1,inhibit,kinase,cysteine,Inhibitor

N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)acrylamide

PF-6274484, 10 mM in DMSO

1035638-91-5