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PHRIXOTOXIN 3

Product Name
PHRIXOTOXIN 3
CAS No.
880886-00-0
Chemical Name
PHRIXOTOXIN 3
Synonyms
PHRIXOTOXIN 3
CBNumber
CB14724231
Molecular Formula
C176H269N51O48S6
Formula Weight
0
MOL File
Mol file
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PHRIXOTOXIN 3 Property

storage temp. 
Store at -20°C
form 
Powder
Water Solubility 
Soluble to 1 mg/ml in water
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4914
Product name
Phrixotoxin3
Packaging
100U
Price
$292
Updated
2021/12/16
Usbiological
Product number
256242
Product name
Phrixotoxin 3
Packaging
100ug
Price
$593
Updated
2021/12/16
ApexBio Technology
Product number
B5764
Product name
Phrixotoxin3
Packaging
100ug
Price
$423
Updated
2021/12/16
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PHRIXOTOXIN 3 Chemical Properties,Usage,Production

Description

Potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV2, NaV3 and NaV5 respectively). Blocks inward sodium currents in a voltage-dependent manner.

Uses

Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current[1].

IC 50

Nav1.3: 42 nM (IC50); Nav1.4: 72 nM (IC50); Nav1.5: 610 nM (IC50); Nav1.2: 0.6 nM (IC50); Nav1.1: 288 nM (IC50)

storage

Store at -20°C

References

[1] Bosmans F, et, al. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Comparative Study Mol Pharmacol. 2006 Feb; 69(2): 419-29. DOI:10.1124/mol.105.015941

PHRIXOTOXIN 3 Preparation Products And Raw materials

Raw materials

Preparation Products

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PHRIXOTOXIN 3 Suppliers

China 25 Japan 1 United Kingdom 1 United States 4 USA 1 Global 32
Creative Peptides
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Email
info@creative-peptides.com
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United States
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6083
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BOC Sciences
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+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
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United States
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19552
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ApexBio Technology
Tel
--
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Email
sales@apexbt.com
Country
United States
ProdList
6251
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58
United States Biological
Tel
--
Fax
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
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80

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  • PHRIXOTOXIN 3
  • 880886-00-0
  • C176H269N51O48S6