ChemicalBook > CAS DataBase List > AG 18

AG 18

Product Name
AG 18
CAS No.
118409-57-7
Chemical Name
AG 18
Synonyms
AG 18;CS-931;TX 825;RG-50810;RG 50858;AG18, >=98%;TYRPHOSTIN 23;TYRPHOSTIN A23;Tyrphostin AG 1;AG-18(RG-50810)
CBNumber
CB2358507
Molecular Formula
C10H6N2O2
Formula Weight
186.17
MOL File
118409-57-7.mol
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AG 18 Property

Melting point:
225°C
Boiling point:
421.1±45.0 °C(Predicted)
Density 
1.428±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO, ethanol, or DMF
pka
7.26±0.18(Predicted)
form 
Yellow solid
color 
Yellow
λmax
464nm(DMSO)(lit.)
Stability:
Store in refrigerator
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Safety

WGK Germany 
3
HS Code 
2926.90.5050
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H371May cause damage to organs

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T7165
Product name
Tyrphostin 23
Purity
≥98%
Packaging
5mg
Price
$130
Updated
2024/03/01
Sigma-Aldrich
Product number
658395
Product name
AG 18
Purity
A broad-spectrum protein tyrosine kinase inhibitor.
Packaging
5mg
Price
$85.2
Updated
2024/03/01
TCI Chemical
Product number
T3503
Product name
Tyrphostin A23
Purity
>98.0%(GC)
Packaging
25mg
Price
$128
Updated
2022/04/27
TCI Chemical
Product number
T3503
Product name
Tyrphostin A23
Purity
>98.0%(GC)
Packaging
100mg
Price
$280
Updated
2024/03/01
Alfa Aesar
Product number
J60308
Product name
Tyrphostin A23, 99%
Packaging
5mg
Price
$73.65
Updated
2024/03/01
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AG 18 Chemical Properties,Usage,Production

Chemical Properties

Yellow Powder

Uses

AG 18 inhibits EGFR with IC50 of 35 μM.

Uses

A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).

Definition

ChEBI: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols.

Biological Activity

Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.

Biochem/physiol Actions

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

AG 18 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 18 Suppliers

Canada 1 China 117 Europe 1 Germany 3 India 4 Japan 1 Switzerland 3 United Kingdom 4 United States 31 Global 165
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View Lastest Price from AG 18 manufacturers

Career Henan Chemical Co
Product
(3,4-Dihydroxybenzylidene)-malononitrile 118409-57-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2019-09-05

118409-57-7, AG 18Related Search:

TYRPHOSTIN A25 AG 213 TYRPHOSTIN AG 126 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) TYRPHOSTIN AG 835 AG 99 TYRPHOSTIN A9 AG 1295 4-HYDROXYBENZYLIDENEMALONONITRILE 4-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylamino)phenol Tyrphostin AG1433 TYRPHOSTIN A1 TYRPHOSTIN AG 1296 XL999 TYRPHOSTIN AG 528 TYRPHOSTIN AG 1288 AG 18 NS-398

  • RARECHEM AL BX 0069
  • RG-50810
  • TYRPHOSTIN RG 50858
  • TYRPHOSTIN AG 18
  • TYRPHOSTIN A23
  • TYRPHOSTIN 23
  • ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMONITRILE
  • AG 18
  • [3,4-DIHYDROXYBENZYLIDENE]MALONONITRILE
  • [(3,4-DIHYDROXYPHENYL)METHYLENE]-PROPENEDINITRILE
  • AG18,RG-50810, Tyrphostin A23, >98%
  • AG 18 - CAS 118409-57-7 - Calbiochem
  • RG-50810; TYRPHOSTIN A23; AG-18; AG18; RG 50810; RG50810
  • CS-931
  • TYRPHOSTIN A23 99+%
  • (3,4-Dihydroxybenzylidene)-malononitrile, RG-50810
  • AG 18 (Tyrphostin A23)
  • 2-(3,4-Dihydroxyphenyl)ethene-1,1-dicarbonitrile
  • 4,5-Dihydroxybenzylidenemalononitrile
  • (3,4-Dihydroxyphenyl)methylene propanedinitrile
  • Propanedinitrile, ((3,4-dihydroxyphenyl)methylene)-
  • AG 18 (Tyrphostin 23)
  • 2-(3,4-Dihydroxybenzylidene)malononitrile
  • AG 18 (pharmaceutical)
  • RG 50858
  • TX 825
  • TYRPHOSTIN 23;AG 18; AG-18; AG18
  • Propanedinitrile, 2-[(3,4-dihydroxyphenyl)methylene]-
  • AG 18 (3,4-Dihydroxybenzylidene)malononitrile 2-(3,4-Dihydroxybenzylidene)malononitrile
  • Tyrphostin AG 1
  • α-Cyano-(3,4-dihydroxy)cinnamonitrile&nbsp
  • AG-18(RG-50810)
  • α-Cyano-(3,4-dihydroxy)cinnamonitrile
  • AG18, >=98%
  • AG 18 (Tyrphostin 23, RG-50810)
  • 2-[(3,4-Dihydroxyphenyl)methylidene]propanedinitrile
  • AG 18 USP/EP/BP
  • AG18，RG-50810， Tyrphostin A23
  • AG-18 (RG50858, TX-825)
  • Tyrphostin A23 AG18
  • Tyrphostin 23,inhibit,RG 50810,EGFR,Inhibitor,HER1,Tyrphostin23,AG-18,AG 18,Epidermal growth factor receptor,RG50810,Tyrphostin A 23,Tyrphostin A-23,ErbB-1,Tyrphostin-23
  • AG-18, EGF receptor kinase inhibitor
  • 118409-57-7
  • C10H6N2O2
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Kinase/Phosphatase Biology
  • Receptor Tyrosine Kinase Inhibitors
  • Epidermal Growth Factor Receptor (EGFR)
  • Intracellular Signaling
  • Protein Kinase
  • All Inhibitors
  • Inhibitors
  • Tyrosine Kinase Inhibitors