AG 18
- Product Name
- AG 18
- CAS No.
- 118409-57-7
- Chemical Name
- AG 18
- Synonyms
- AG 18;CS-931;TX 825;RG-50810;RG 50858;AG18, >=98%;TYRPHOSTIN 23;TYRPHOSTIN A23;Tyrphostin AG 1;AG-18(RG-50810)
- CBNumber
- CB2358507
- Molecular Formula
- C10H6N2O2
- Formula Weight
- 186.17
- MOL File
- 118409-57-7.mol
AG 18 Property
- Melting point:
- 225°C
- Boiling point:
- 421.1±45.0 °C(Predicted)
- Density
- 1.428±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO, ethanol, or DMF
- pka
- 7.26±0.18(Predicted)
- form
- Yellow solid
- color
- Yellow
- λmax
- 464nm(DMSO)(lit.)
- Stability:
- Store in refrigerator
Safety
- WGK Germany
- 3
- HS Code
- 2926.90.5050
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H371May cause damage to organs
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T7165
- Product name
- Tyrphostin 23
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 658395
- Product name
- AG 18
- Purity
- A broad-spectrum protein tyrosine kinase inhibitor.
- Packaging
- 5mg
- Price
- $85.2
- Updated
- 2024/03/01
- Product number
- T3503
- Product name
- Tyrphostin A23
- Purity
- >98.0%(GC)
- Packaging
- 25mg
- Price
- $128
- Updated
- 2022/04/27
- Product number
- T3503
- Product name
- Tyrphostin A23
- Purity
- >98.0%(GC)
- Packaging
- 100mg
- Price
- $280
- Updated
- 2024/03/01
- Product number
- J60308
- Product name
- Tyrphostin A23, 99%
- Packaging
- 5mg
- Price
- $73.65
- Updated
- 2024/03/01
AG 18 Chemical Properties,Usage,Production
Chemical Properties
Yellow Powder
Uses
AG 18 inhibits EGFR with IC50 of 35 μM.
Uses
A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).
Definition
ChEBI: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols.
Biological Activity
Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.
Biochem/physiol Actions
Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
AG 18 Preparation Products And Raw materials
Raw materials
Preparation Products
AG 18 Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from AG 18 manufacturers
- Product
- (3,4-Dihydroxybenzylidene)-malononitrile 118409-57-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20kg
- Release date
- 2019-09-05