AG 18

Product Name: AG 18
CAS No.: 118409-57-7
Chemical Name: AG 18
Synonyms: AG 18;CS-931;TX 825;RG-50810;RG 50858;AG18, >=98%;TYRPHOSTIN 23;TYRPHOSTIN A23;Tyrphostin AG 1;AG-18(RG-50810)
CBNumber: CB2358507
Molecular Formula: C10H6N2O2
Formula Weight: 186.17
MOL File: 118409-57-7.mol

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AG 18 Property

Melting point:: 225°C
Boiling point:: 421.1±45.0 °C(Predicted)
Density: 1.428±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO, ethanol, or DMF
pka: 7.26±0.18(Predicted)
form: Yellow solid
color: Yellow
λmax: 464nm(DMSO)(lit.)
Stability:: Store in refrigerator

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Safety

WGK Germany: 3
HS Code: 2926.90.5050

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H371May cause damage to organs

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T7165
Product name: Tyrphostin 23
Purity: ≥98%
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Sigma-Aldrich

Product number: 658395
Product name: AG 18
Purity: A broad-spectrum protein tyrosine kinase inhibitor.
Packaging: 5mg
Price: $85.2
Updated: 2024/03/01

TCI Chemical

Product number: T3503
Product name: Tyrphostin A23
Purity: >98.0%(GC)
Packaging: 25mg
Price: $128
Updated: 2022/04/27

TCI Chemical

Product number: T3503
Product name: Tyrphostin A23
Purity: >98.0%(GC)
Packaging: 100mg
Price: $280
Updated: 2024/03/01

Alfa Aesar

Product number: J60308
Product name: Tyrphostin A23, 99%
Packaging: 5mg
Price: $73.65
Updated: 2024/03/01

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AG 18 Chemical Properties,Usage,Production

Chemical Properties

Yellow Powder

Uses

AG 18 inhibits EGFR with IC50 of 35 μM.

Uses

A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).

Definition

ChEBI: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols.

Biological Activity

Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.

Biochem/physiol Actions

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

AG 18 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 18 Suppliers

Canada 1 China 117 Europe 1 Germany 3 India 4 Japan 1 Switzerland 3 United Kingdom 4 United States 30 Global 164

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
Advantage: 55

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View Lastest Price from AG 18 manufacturers

Career Henan Chemical Co

Product: (3,4-Dihydroxybenzylidene)-malononitrile 118409-57-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

118409-57-7, AG 18Related Search:

TYRPHOSTIN A25 AG 213 TYRPHOSTIN AG 126 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) TYRPHOSTIN AG 835 AG 99 TYRPHOSTIN A9 AG 1295 4-HYDROXYBENZYLIDENEMALONONITRILE 4-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylamino)phenol Tyrphostin AG1433 TYRPHOSTIN A1 TYRPHOSTIN AG 1296 XL999 TYRPHOSTIN AG 528 TYRPHOSTIN AG 1288 AG 18 NS-398

RARECHEM AL BX 0069

RG-50810

TYRPHOSTIN RG 50858

TYRPHOSTIN AG 18

TYRPHOSTIN A23

TYRPHOSTIN 23

ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMONITRILE

AG 18

[3,4-DIHYDROXYBENZYLIDENE]MALONONITRILE

[(3,4-DIHYDROXYPHENYL)METHYLENE]-PROPENEDINITRILE

AG18,RG-50810, Tyrphostin A23, >98%

AG 18 - CAS 118409-57-7 - Calbiochem

RG-50810; TYRPHOSTIN A23; AG-18; AG18; RG 50810; RG50810

CS-931

TYRPHOSTIN A23 99+%

(3,4-Dihydroxybenzylidene)-malononitrile, RG-50810

AG 18 (Tyrphostin A23)

2-(3,4-Dihydroxyphenyl)ethene-1,1-dicarbonitrile

4,5-Dihydroxybenzylidenemalononitrile

(3,4-Dihydroxyphenyl)methylene propanedinitrile

Propanedinitrile, ((3,4-dihydroxyphenyl)methylene)-

AG 18 (Tyrphostin 23)

2-(3,4-Dihydroxybenzylidene)malononitrile

AG 18 (pharmaceutical)

RG 50858

TX 825

TYRPHOSTIN 23;AG 18; AG-18; AG18

Propanedinitrile, 2-[(3,4-dihydroxyphenyl)methylene]-

AG 18 (3,4-Dihydroxybenzylidene)malononitrile 2-(3,4-Dihydroxybenzylidene)malononitrile

Tyrphostin AG 1

α-Cyano-(3,4-dihydroxy)cinnamonitrile&nbsp

AG-18(RG-50810)

α-Cyano-(3,4-dihydroxy)cinnamonitrile

AG18, >=98%

AG 18 (Tyrphostin 23, RG-50810)

2-[(3,4-Dihydroxyphenyl)methylidene]propanedinitrile

AG 18 USP/EP/BP

AG18，RG-50810， Tyrphostin A23

AG-18 (RG50858, TX-825)

Tyrphostin A23 AG18

Tyrphostin 23,inhibit,RG 50810,EGFR,Inhibitor,HER1,Tyrphostin23,AG-18,AG 18,Epidermal growth factor receptor,RG50810,Tyrphostin A 23,Tyrphostin A-23,ErbB-1,Tyrphostin-23

118409-57-7

C10H6N2O2

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Kinase/Phosphatase Biology

Receptor Tyrosine Kinase Inhibitors

Epidermal Growth Factor Receptor (EGFR)

Intracellular Signaling

Protein Kinase

All Inhibitors

Inhibitors

Tyrosine Kinase Inhibitors