ChemicalBook > CAS DataBase List > 4,6-Dichloro-5-methoxypyrimidine

4,6-Dichloro-5-methoxypyrimidine

Product Name
4,6-Dichloro-5-methoxypyrimidine
CAS No.
5018-38-2
Chemical Name
4,6-Dichloro-5-methoxypyrimidine
Synonyms
2,4-dimethoxy-2-methylmercapyrimidine;6-Dichloro-5-MethoxypyriMidine;4,6-Dichlor-5-methoxypyrimidin;5-methox-4,6-Dichloropyrimidin;2,4-Dichloro-5-MetoxyPyriMidine;5-Methoxy-4,6-dichloropyriMidine;4,6-DICHLORO-5-METHOXYPYRIMIDINE;4,6-Dichloro-5-methoxy-1,3-diazine;Pyrimidine, 4,6-dichloro-5-methoxy-;4,6 -Dicholoro-5 Methoxy Pyrimidine
CBNumber
CB2390639
Molecular Formula
C5H4Cl2N2O
Formula Weight
179
MOL File
5018-38-2.mol
More
Less

4,6-Dichloro-5-methoxypyrimidine Property

Melting point:
54-58 °C
Boiling point:
257.8±35.0 °C(Predicted)
Density 
1.446±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Dichloromethane (Slightly)
form 
Solid
pka
-4.13±0.26(Predicted)
color 
White
InChI
InChI=1S/C5H4Cl2N2O/c1-10-3-4(6)8-2-9-5(3)7/h2H,1H3
InChIKey
IJQIGKLDBGKSNT-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=C(OC)C(Cl)=N1
CAS DataBase Reference
5018-38-2(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-41
Safety Statements 
26-39
WGK Germany 
3
HS Code 
2933599590
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
706485
Product name
4,6-Dichloro-5-methoxypyrimidine
Purity
97%
Packaging
1g
Price
$80.9
Updated
2023/06/20
TCI Chemical
Product number
D4723
Product name
4,6-Dichloro-5-methoxypyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
D4723
Product name
4,6-Dichloro-5-methoxypyrimidine
Purity
>98.0%(GC)
Packaging
25g
Price
$104
Updated
2025/07/31
TRC
Product number
D435285
Product name
4,6-Dichloro-5-methoxypyrimidine
Packaging
10g
Price
$110
Updated
2021/12/16
Usbiological
Product number
295951
Product name
4,6-Dichloro-5-methoxypyrimidine
Packaging
5g
Price
$345
Updated
2021/12/16
More
Less

4,6-Dichloro-5-methoxypyrimidine Chemical Properties,Usage,Production

Chemical Properties

Off-white solid

Uses

4,6-Dichloro-5-methoxypyrimidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

5193-84-0

5018-38-2

Example 3.2 Preparation of 4,6-dichloro-5-methoxypyrimidine: 5-methoxypyrimidine-4,6-diol (96.0 g, 676 mmol) and triethylamine (95.0 mL, 680 mmol) were suspended in anhydrous toluene (1.2 L) and heated to 100-105°C. A solution of anhydrous toluene (200 mL) with trichlorophosphate (140 mL, 1.5 mol) was added slowly and dropwise over 30 min. The reaction mixture was refluxed for 1 hour and cooled to room temperature. The toluene layer was decanted and ice water was added to the residue. The heavier black oil layer was separated, dilution was continued with ice water, and the mixture was extracted with toluene (2 x 200 mL). The toluene extracts were combined and the aqueous layer discarded. The organic phase was washed sequentially with saturated sodium bicarbonate solution (2×300 mL), saturated saline (400 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford the title compound 4,6-dichloro-5-methoxypyrimidine (103.4 g, 86% yield) as a white solid.1H NMR (CDCl3) δ 4.00 (s, 3H), 8.55 (s, 1H).

References

[1] Patent: US2009/286816, 2009, A1. Location in patent: Page/Page column 12
[2] Patent: EP714896, 1996, A1
[3] Patent: US2006/52398, 2006, A1. Location in patent: Page/Page column 39
[4] Patent: US5300506, 1994, A
[5] Patent: US5077293, 1991, A

4,6-Dichloro-5-methoxypyrimidine Preparation Products And Raw materials

Raw materials

4,6-Dihydroxy-5-methoxypyrimidine Phosphorus oxitrichloride

Preparation Products

More
Less

4,6-Dichloro-5-methoxypyrimidine Suppliers

Americas 1 Canada 2 China 220 Europe 3 Germany 6 India 13 Japan 1 Slovakia 1 United Kingdom 14 United States 41 Global 302
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Accela ChemBio Inc.
Tel
+1(858) 699-3322
Fax
+1(858) 876-1948
Email
marketing@accelachem.com
Country
United States
ProdList
6024
Advantage
65
Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
Advantage
60
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Alfa Chemistry
Tel
+1-5166625404;
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
20405
Advantage
58
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
21193
Advantage
58
Cato Research Chemicals Inc.
Tel
+86-020-81960175-877 4000-868-328
Email
tianwen.zhan@cato-chem.com
Country
United States
ProdList
10404
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
Wilshire Technologies, Inc.
Tel
--
Fax
--
Email
info@wilshiretechnologies.com
Country
United States
ProdList
893
Advantage
58
Chemphtec Corporation
Tel
--
Fax
--
Email
fo@chemphtec.com
Country
United States
ProdList
2181
Advantage
58
Wilshire Technologies
Tel
--
Fax
--
Country
United States
ProdList
428
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Chiral Management
Tel
--
Fax
--
Email
sales@chiralmanagement.com
Country
United States
ProdList
1332
Advantage
30
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
Synthonix
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
1423
Advantage
68
Precursor Chemicals, Inc.
Tel
--
Fax
--
Email
info@precursorchem.com
Country
United States
ProdList
347
Advantage
51
Louston International
Tel
--
Fax
--
Email
sales@louston.com
Country
United States
ProdList
525
Advantage
58
ChemContract Research Inc.
Tel
--
Fax
--
Country
United States
ProdList
1526
Advantage
38
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
AnsisChem
Tel
--
Fax
--
Country
United States
ProdList
409
Advantage
38
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
More
Less

View Lastest Price from 4,6-Dichloro-5-methoxypyrimidine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4,6-Dichloro-5-methoxypyrimidine 5018-38-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28
R&D Scientific Inc.
Product
4,6-Dichloro-5-methoxypyrimidine 5018-38-2
Price
US $520.00/Kg
Min. Order
0.100Kg
Purity
99 %
Supply Ability
5000 Kg
Release date
2025-04-09
Shaanxi Dideu New Materials Co. Ltd
Product
4,6-Dichloro-5-methoxypyrimidine 5018-38-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-27

5018-38-2, 4,6-Dichloro-5-methoxypyrimidineRelated Search:

2,4-Dichloro-5-methylpyrimidine (Trifluoromethoxy)benzene 4-Methoxyphenylacetone 3-Methoxybenzaldehyde Anisole 4,6-Dichloropyrimidine p-Anisaldehyde p-Anisidine 4-Methoxybenzylchloride Sulfadiazine Pyrimidine 2,4-DICHLORO-5-METHOXYPYRIMIDINE, 98+%,2,4-Dichloro-5-methoxypyrimidine,2,4-DICHLORO-5-METHOXYPYRIMIDINE, 98+%,2,4-Dichloro-5-methoxypyrimidine 2,4-Dichloro-6-methoxypyrimidine,2,4-Dichloro-6-methoxypyrimidine 2-Methoxy-4,6-dichloropyrimidine 5-Hydroxypyrimidine 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine 4,6-Dichloro-5-methoxypyrimidine

  • 2,4-dimethoxy-2-methylmercapyrimidine
  • 4,6-Dichlor-5-methoxypyrimidin
  • 4,6-DICHLORO-5-METHOXYPYRIMIDINE
  • 4,6-DICHLORO-5-METHOXYPYRIMIDINE 99%
  • Pyrimidine, 4,6-dichloro-5-methoxy-
  • 2,4-Dichloro-5-MetoxyPyriMidine
  • 5-Methoxy-4,6-dichloropyriMidine
  • 4,6-Dichloro-5-methoxy-1,3-diazine
  • 6-Dichloro-5-MethoxypyriMidine
  • 4,6 -Dicholoro-5 Methoxy Pyrimidine
  • 4,6-Dichloro-5-methoxypyrimidine &gt
  • 4,6-Dichloro-5-methoxypyrimidine ISO 9001：2015 REACH
  • 5-methox-4,6-Dichloropyrimidin
  • 5018-38-2 4,6-Dichloro-5-methoxypyrimidine
  • 4,6-Dichloro-5-methoxypyrimidine, CAS 5018-38-2
  • 5018-38-2
  • C5H4N2OCl2
  • Heterocycle-Pyrimidine series
  • Halides
  • Pyrazines, Pyrimidines & Pyridazines
  • Pyrimidine Derivertives
  • Pyrimidine series
  • APIs & Intermediate
  • Pyrimidine