ChemicalBook > CAS DataBase List > 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide

Product Name
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide
CAS No.
944261-79-4
Chemical Name
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide
Synonyms
brgt;CS-374;A 803467;[3H]-A-803467;A-803467, >98%;A-803467, >=99%;A803467;A 803467;-dimethoxyphenylamide;5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-;5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
CBNumber
CB31471262
Molecular Formula
C19H16ClNO4
Formula Weight
357.79
MOL File
944261-79-4.mol
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5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Property

Melting point:
128-130?C
Boiling point:
450.6±45.0 °C(Predicted)
Density 
1.294±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: >10mg/mL
form 
powder
pka
11.72±0.70(Predicted)
color 
white to tan
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A3109
Product name
A-803467
Purity
≥98% (HPLC)
Packaging
10mg
Price
$174
Updated
2024/03/01
Sigma-Aldrich
Product number
A3109
Product name
A-803467
Purity
≥98% (HPLC)
Packaging
50mg
Price
$279.6
Updated
2024/03/01
Alfa Aesar
Product number
J67281
Product name
A-803467, 98%
Packaging
5mg
Price
$78.2
Updated
2023/06/20
Alfa Aesar
Product number
J67281
Product name
A-803467, 98%
Packaging
10mg
Price
$120
Updated
2021/12/16
Cayman Chemical
Product number
10012588
Product name
A-803467
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
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5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Chemical Properties,Usage,Production

Description

Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Nav1.8 sodium channels (IC50 = 8 nM when stimulated at half-maximal inactivation and IC50 = 79 nM at a resting state). This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train. A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

Chemical Properties

White Solid

Uses

A selective NaV1.8 sodium channel blocker, reduces behavioral measures of chronic pain. Analgesic.

General Description

The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.

Biological Activity

Selective blocker of Na V 1.8 channels (IC 50 values are 8, 2450, 6740, 7340 and 7380 nM for hNa V 1.8, hNa V 1.3, hNa V 1.7, hNa V 1.5 and hNa V 1.2 channels respectively). Shows no significant activity against TRPV1, P2X 2/3 , Ca V 2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

Biochem/physiol Actions

A-803467 blocks Nav1.8 in both half-maximal inactive and resting states with an IC50 of 8 nM and IC50 of 79 nM, respectively. A-803467 is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.

storage

+4°C

References

1) Jarvis et al. (2007), A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat; Proc. Natl. Acad. Sci. USA, 104 8520 2) McGaraughty et al. (2008), A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats; J. Pharmacol. Exp. Ther., 324 1204

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Suppliers

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View Lastest Price from 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide manufacturers

Career Henan Chemical Co
Product
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide 944261-79-4
Price
US $1.00/KG
Min. Order
1KG
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

944261-79-4, 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamideRelated Search:

Ranolazine dihydrochloride Tetracaine hydrochloride Aconitine VERATRIDINE TETRODOTOXIN QX-314 L-KAWAIN BENZAMIL HYDROCHLORIDE Procainamide hydrochloride Linocaine hydrochloride Bupivacaine Hydrochloride Lamotrigine N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride SDZ-201 106 (+/-) PD 85639 BATRACHOTOXIN A-803467 CHEMBRDG-BB 5929971

  • 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide
  • 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
  • A 803467
  • 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-
  • 5-4(-Chlorophenyl)-N-(3,5-diMethoxyphenyl)furan-2-carboxaMide
  • 2-FurancarboxaMide,5-(4-chlorophenyl)-N-(3,5-diMethoxyphenyl)-
  • 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
  • A-803467, >=99%
  • A803467;A 803467
  • 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5lt
  • brgt
  • -dimethoxyphenylamide
  • A-803467, >98%
  • CS-374
  • [3H]-A-803467
  • 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5-dimethoxyphenylamide USP/EP/BP
  • 944261-79-4
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  • Inhibitors
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