Propargyl-PEG4-S-PEG4-acid

Product Name: Propargyl-PEG4-S-PEG4-acid
CAS No.: 2055041-20-6
Chemical Name: Propargyl-PEG4-S-PEG4-acid
Synonyms: Propargyl-PEG4-S-PEG4-acid;4,7,10,13,19,22,25,28-Octaoxa-16-thiahentriacont-30-ynoic acid;3-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethylsulfanyl]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
CBNumber: CB33163110
Molecular Formula: C22H40O10S
Formula Weight: 496.61
MOL File: 2055041-20-6.mol

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Propargyl-PEG4-S-PEG4-acid Property

Boiling point:: 591.5±50.0 °C(Predicted)
Density: 1.141±0.06 g/cm3(Predicted)
pka: 4.28±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23191
Product name: Propargyl-PEG4-S-PEG4-acid
Purity: 98%
Packaging: 1g
Price: $1400
Updated: 2021/12/16

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Propargyl-PEG4-S-PEG4-acid Chemical Properties,Usage,Production

Description

Propargyl-PEG4-S-PEG4-acid is a PEG linker containing a propargyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Propargyl-PEG4-S-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-S-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Propargyl-PEG4-S-PEG4-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargyl-PEG4-S-PEG4-acid Suppliers

China 16 United States 2 Global 18

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

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View Lastest Price from Propargyl-PEG4-S-PEG4-acid manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Propargyl-PEG4-S-PEG4-acid 2055041-20-6
Price: US $0.00/mg
Min. Order: 500mg
Purity: >95.00%
Supply Ability: 500mg
Release date: 2024-03-28

2055041-20-6, Propargyl-PEG4-S-PEG4-acidRelated Search:

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Propargyl-PEG4-S-PEG4-acid

4,7,10,13,19,22,25,28-Octaoxa-16-thiahentriacont-30-ynoic acid

3-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethylsulfanyl]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

2055041-20-6

C22H40O10S