ChemicalBook > CAS DataBase List > OXAMFLATIN

OXAMFLATIN

Product Name
OXAMFLATIN
CAS No.
151720-43-3
Chemical Name
OXAMFLATIN
Synonyms
CS-2473;Metacept 3;METACEPT 3;OXAMFLATIN;Oxamflatin (Metacept-3);(E)-N-hydroxy-5-(3-(phenylsulfonaMido)phenyl)pent-2-en-4-ynaMide;(2E)-N-Hydroxy-5-[3-[(Phenylsulfonyl)Amino]Phenyl]-2-Penten-4-Ynamide;2-Penten-4-ynamide, N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-, (2E)-
CBNumber
CB3504059
Molecular Formula
C17H14N2O4S
Formula Weight
342.37
MOL File
151720-43-3.mol
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OXAMFLATIN Property

Melting point:
98-100°C
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 13 mg/mL, soluble
form 
solid
pka
7.75±0.10(Predicted)
Stability:
Light sensitive
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O3139
Product name
Oxamflatin
Purity
≥98% (HPLC), solid
Packaging
1mg
Price
$187
Updated
2024/03/01
Sigma-Aldrich
Product number
O3139
Product name
Oxamflatin
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$656
Updated
2024/03/01
Cayman Chemical
Product number
13176
Product name
Oxamflatin
Purity
≥95%
Packaging
1mg
Price
$77
Updated
2024/03/01
Cayman Chemical
Product number
13176
Product name
Oxamflatin
Purity
≥95%
Packaging
5mg
Price
$340
Updated
2024/03/01
Cayman Chemical
Product number
13176
Product name
Oxamflatin
Purity
≥95%
Packaging
10mg
Price
$602
Updated
2024/03/01
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OXAMFLATIN Chemical Properties,Usage,Production

Chemical Properties

Red-Brown Solid

Uses

Histone deacetylase inhibitor. A cell-permeable, aromatic sulfonamide derivative with a hydroxamic acid group that potently inhibits mammalian HDAC by binding to the active site zinc.

Definition

ChEBI: 5-[3-(benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamide is a sulfonamide.

Enzyme inhibitor

This anti-tumor agent (FW = 342.38 g/mol; CAS 151720-43-3; Solubility: 13 mg/mL DMSO, methanol, acetonitrile, 10 mg/mL), also known as (2E)- 5-[3-[(phenylsulfonyl)amino]phenyl]-pent-2-en-4-ynohydroxamate, inhibits histone deacetylase. Oxamflatin shows antiproliferative activity in vitro against various mouse and human tumor cell lines, attended by drastic changes in the cell morphology and in vivo antitumor activity against B16 melanoma. Oxamflatin causes an elongated cell shape with filamentous protrusions as well as arrest of the cell cycle at the G1 phase in HeLa cells. These phenotypic changes in HeLa cells were similar to those induced by trichostatin A (TSA), a specific inhibitor of histone deacetylase (HDAC).

OXAMFLATIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from OXAMFLATIN manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Oxamflatin 151720-43-3
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2021-09-13
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Oxamflatin 151720-43-3
Price
US $100.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-09-14
Career Henan Chemical Co
Product
OXAMFLATIN 151720-43-3
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-26

151720-43-3, OXAMFLATINRelated Search:


  • CS-2473
  • Metacept 3
  • METACEPT 3;OXAMFLATIN
  • (E)-N-hydroxy-5-(3-(phenylsulfonaMido)phenyl)pent-2-en-4-ynaMide
  • (2E)-N-Hydroxy-5-[3-[(Phenylsulfonyl)Amino]Phenyl]-2-Penten-4-Ynamide
  • Oxamflatin (Metacept-3)
  • 2-Penten-4-ynamide, N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-, (2E)-
  • 151720-43-3
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Antitumour
  • Amines
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals