OXAMFLATIN

ChemicalBook > CAS DataBase List > OXAMFLATIN

Product Name: OXAMFLATIN
CAS No.: 151720-43-3
Chemical Name: OXAMFLATIN
Synonyms: CS-2473;Metacept 3;METACEPT 3;OXAMFLATIN;Oxamflatin (Metacept-3);Oxamflatin, HDAC inhibitor;(E)-N-hydroxy-5-(3-(phenylsulfonaMido)phenyl)pent-2-en-4-ynaMide;(2E)-N-Hydroxy-5-[3-[(Phenylsulfonyl)Amino]Phenyl]-2-Penten-4-Ynamide;2-Penten-4-ynamide, N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-, (2E)-
CBNumber: CB3504059
Molecular Formula: C17H14N2O4S
Formula Weight: 342.37
MOL File: 151720-43-3.mol

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OXAMFLATIN Property

Melting point:: 98-100°C
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 13 mg/mL, soluble
form: solid
pka: 7.75±0.10(Predicted)
color: Light yellow to yellow
Stability:: Light sensitive

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O3139
Product name: Oxamflatin
Purity: ≥98% (HPLC), solid
Packaging: 1mg
Price: $187
Updated: 2024/03/01

Sigma-Aldrich

Product number: O3139
Product name: Oxamflatin
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $656
Updated: 2024/03/01

Cayman Chemical

Product number: 13176
Product name: Oxamflatin
Purity: ≥95%
Packaging: 1mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 13176
Product name: Oxamflatin
Purity: ≥95%
Packaging: 5mg
Price: $340
Updated: 2024/03/01

Cayman Chemical

Product number: 13176
Product name: Oxamflatin
Purity: ≥95%
Packaging: 10mg
Price: $602
Updated: 2024/03/01

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OXAMFLATIN Chemical Properties,Usage,Production

Chemical Properties

Red-Brown Solid

Uses

Histone deacetylase inhibitor. A cell-permeable, aromatic sulfonamide derivative with a hydroxamic acid group that potently inhibits mammalian HDAC by binding to the active site zinc.

Definition

ChEBI: 5-[3-(benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamide is a sulfonamide.

Enzyme inhibitor

This anti-tumor agent (FW = 342.38 g/mol; CAS 151720-43-3; Solubility: 13 mg/mL DMSO, methanol, acetonitrile, 10 mg/mL), also known as (2E)- 5-[3-[(phenylsulfonyl)amino]phenyl]-pent-2-en-4-ynohydroxamate, inhibits histone deacetylase. Oxamflatin shows antiproliferative activity in vitro against various mouse and human tumor cell lines, attended by drastic changes in the cell morphology and in vivo antitumor activity against B16 melanoma. Oxamflatin causes an elongated cell shape with filamentous protrusions as well as arrest of the cell cycle at the G1 phase in HeLa cells. These phenotypic changes in HeLa cells were similar to those induced by trichostatin A (TSA), a specific inhibitor of histone deacetylase (HDAC).

OXAMFLATIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from OXAMFLATIN manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Oxamflatin 151720-43-3
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-13

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Oxamflatin 151720-43-3
Price: US $100.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-14

Career Henan Chemical Co

Product: OXAMFLATIN 151720-43-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-26

151720-43-3, OXAMFLATINRelated Search:

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CS-2473

Metacept 3

METACEPT 3;OXAMFLATIN

(E)-N-hydroxy-5-(3-(phenylsulfonaMido)phenyl)pent-2-en-4-ynaMide

(2E)-N-Hydroxy-5-[3-[(Phenylsulfonyl)Amino]Phenyl]-2-Penten-4-Ynamide

Oxamflatin (Metacept-3)

2-Penten-4-ynamide, N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-, (2E)-

Oxamflatin, HDAC inhibitor

151720-43-3

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