OXAMFLATIN
- Product Name
- OXAMFLATIN
- CAS No.
- 151720-43-3
- Chemical Name
- OXAMFLATIN
- Synonyms
- CS-2473;Metacept 3;METACEPT 3;OXAMFLATIN;Oxamflatin (Metacept-3);(E)-N-hydroxy-5-(3-(phenylsulfonaMido)phenyl)pent-2-en-4-ynaMide;(2E)-N-Hydroxy-5-[3-[(Phenylsulfonyl)Amino]Phenyl]-2-Penten-4-Ynamide;2-Penten-4-ynamide, N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-, (2E)-
- CBNumber
- CB3504059
- Molecular Formula
- C17H14N2O4S
- Formula Weight
- 342.37
- MOL File
- 151720-43-3.mol
OXAMFLATIN Property
- Melting point:
- 98-100°C
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 13 mg/mL, soluble
- form
- solid
- pka
- 7.75±0.10(Predicted)
- Stability:
- Light sensitive
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- O3139
- Product name
- Oxamflatin
- Purity
- ≥98% (HPLC), solid
- Packaging
- 1mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- O3139
- Product name
- Oxamflatin
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $656
- Updated
- 2024/03/01
- Product number
- 13176
- Product name
- Oxamflatin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 13176
- Product name
- Oxamflatin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $340
- Updated
- 2024/03/01
- Product number
- 13176
- Product name
- Oxamflatin
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $602
- Updated
- 2024/03/01
OXAMFLATIN Chemical Properties,Usage,Production
Chemical Properties
Red-Brown Solid
Uses
Histone deacetylase inhibitor. A cell-permeable, aromatic sulfonamide derivative with a hydroxamic acid group that potently inhibits mammalian HDAC by binding to the active site zinc.
Definition
ChEBI: 5-[3-(benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamide is a sulfonamide.
Enzyme inhibitor
This anti-tumor agent (FW = 342.38 g/mol; CAS 151720-43-3; Solubility: 13 mg/mL DMSO, methanol, acetonitrile, 10 mg/mL), also known as (2E)- 5-[3-[(phenylsulfonyl)amino]phenyl]-pent-2-en-4-ynohydroxamate, inhibits histone deacetylase. Oxamflatin shows antiproliferative activity in vitro against various mouse and human tumor cell lines, attended by drastic changes in the cell morphology and in vivo antitumor activity against B16 melanoma. Oxamflatin causes an elongated cell shape with filamentous protrusions as well as arrest of the cell cycle at the G1 phase in HeLa cells. These phenotypic changes in HeLa cells were similar to those induced by trichostatin A (TSA), a specific inhibitor of histone deacetylase (HDAC).
OXAMFLATIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from OXAMFLATIN manufacturers
- Product
- Oxamflatin 151720-43-3
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2021-09-13
- Product
- Oxamflatin 151720-43-3
- Price
- US $100.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-09-14
- Product
- OXAMFLATIN 151720-43-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-26