6-CHLORO-2-PICOLINIC ACID METHYL ESTER

Product Name: 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
CAS No.: 6636-55-1
Chemical Name: 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
Synonyms: AKOS BBS-00004651;Sorafenib Impurity 117;methyl 6-chloropicolinate;6-Chloropicolinic acid methyl ester;methyl (6-chloropyridin-2-yl)acetate;methyl 6-chloro-2-pyridinecarboxylate;METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE;2-chloropyridine-6-carboxylate methyl;methyl 2-(6-chloropyridin-2-yl)acetate;6-CHLORO-2-PICOLINIC ACID METHYL ESTER
CBNumber: CB3780710
Molecular Formula: C7H6ClNO2
Formula Weight: 171.58
MOL File: 6636-55-1.mol

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6-CHLORO-2-PICOLINIC ACID METHYL ESTER Property

Melting point:: 93-94°
Boiling point:: 275.8±20.0 °C(Predicted)
Density: 1.294±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: -1.03±0.10(Predicted)
form: Solid
color: Pale yellow
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C7H6ClNO2/c1-11-7(10)5-3-2-4-6(8)9-5/h2-4H,1H3
InChIKey: TWUXBVMXSBEKHA-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC(Cl)=CC=C1

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2640
Product name: Methyl 6-Chloro-2-pyridinecarboxylate
Purity: >98.0%(GC)
Packaging: 1g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: M2640
Product name: Methyl 6-Chloro-2-pyridinecarboxylate
Purity: >98.0%(GC)
Packaging: 5g
Price: $31
Updated: 2025/07/31

TRC

Product number: C379663
Product name: 6-Chloro-2-picolinicacidmethylester
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: C379663
Product name: 6-Chloro-2-picolinicacidmethylester
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 048113
Product name: Methyl 6-chloro-2-pyridinecarboxylate
Purity: 95+%
Packaging: 5g
Price: $23
Updated: 2021/12/16

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6-CHLORO-2-PICOLINIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Methyl 6-chloropyridine-2-carboxylate was coupled with 2-(trimethylstannyl)pyridine to afford methyl 2,2?-bipyridine-6-carboxylate.

Synthesis Reference(s)

Synthetic Communications, 14, p. 77, 1984 DOI: 10.1080/00397918408060867

Synthesis

6-Chloro-2-picolinic acid methyl ester is prepared by the reaction of methanol and 6-Chloropicolinic acid. The specific synthesis steps are as follows:
Add thionyl chloride (3.7 ml, 50.8 mmol) to a solution of 6-chloropicolinic acid (4.0 g, 25.4 mmol) in methanol (85 ml) at 0 C. Stir the resultant solution for 15 minutes at 0 C, 0.5 hours at room temperature, and 6 hours at 50 C. Concentrate the reaction in vacuo and dilute with CHCl3 (150ml). Wash the organic solution with saturated aqueous sodium bicarbonate (3 x 100 ml), and brine (1 x 100 ml) and dry with sodium sulfate. Filtration and concentration afford methyl 6-chloropicolinate 4.38 g (100 percent) as a white solid. 1H NMR (CDCl3): δ 8.05 (m, 1H), 7.73 (m, 1H), 7.42 (m, 1H), 3.95 (s, 3H).

References

[1] Patent: WO2004/26871, 2004, A1. Location in patent: Page 43
[2] Patent: WO2007/58482, 2007, A1. Location in patent: Page/Page column 47
[3] Patent: WO2013/102431, 2013, A1. Location in patent: Page/Page column 117
[4] Patent: WO2015/6592, 2015, A1. Location in patent: Page/Page column 52; 53

6-CHLORO-2-PICOLINIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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6-CHLORO-2-PICOLINIC ACID METHYL ESTER Suppliers

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View Lastest Price from 6-CHLORO-2-PICOLINIC ACID METHYL ESTER manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: Methyl 6-chloropicolinate 6636-55-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

Henan Aochuang Chemical Co.,Ltd.

Product: 6-CHLORO-2-PICOLINIC ACID METHYL ESTER 6636-55-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

Henan Fengda Chemical Co., Ltd

Product: 6-CHLORO-2-PICOLINIC ACID METHYL ESTER 6636-55-1
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

6636-55-1, 6-CHLORO-2-PICOLINIC ACID METHYL ESTERRelated Search:

6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE Methyl 6-bromonicotinate METHYL 6-FORMYLNICOTINATE methyl 6-chloropyrimidine-4-carboxylate Methyl 6-bromoisoquinoline-1-carboxylate Methyl 6-bromohexanoate Methyl 6-chloronicotinate METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE methyl 6-methylpyridine-2-carboxylate 6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Methyl 6-bromo-2-naphthoate 6-METHYLPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER 2-Chloro-6-pyrazinecarboxylic acid methyl ester Methyl 6-HydroxypyriMidine-4-carboxylate Methyl 6-methylnicotinate Methyl 3-chloropicolinate 6-Chloropicolinic acid

Methyl 6-Chloropyridine-2-carboxylate, 97+%

METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE

AKOS BBS-00004651

6-CHLOROPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

6-CHLORO-2-PICOLINIC ACID METHYL ESTER

6-Chloro-2-pyridinecarboxylic acid methyl ester

6-Chloropicolinic acid methyl ester

2-Pyridinecarboxylic acid, 6-chloro-, methyl ester

methyl 6-chloro-2-pyridinecarboxylate

methyl 2-(6-chloropyridin-2-yl)acetate

methyl 6-chloropicolinate

methyl (6-chloropyridin-2-yl)acetate

2-chloropyridine-6-carboxylate methyl

6-chloro-2-picolonic acid methyl ester

Methyl 6-chloropicolinate, 2-Chloro-6-(methoxycarbonyl)pyridine

6-Chloro-2-picolinic acid methyl ester Solution

Methyl 6-Chloro-2-pyridinecarboxylate &gt

Methyl6-chloropyridine-2-carboxylate,95%

6-CHLORO-2-PICOLINIC ACID METHYL ESTER ISO 9001：2015 REACH

Sorafenib Impurity 117

6-Chloro-2-picolinic acid methyl ester Solution in Hexane

Methyl 6-chloro-2-pyridinecarboxylate,Methyl 6-chloropicolinate,6-Chloro-2-pyridinecarboxylic acid methyl ester,6-Chloropicolinic acid methyl ester,2-Pyridinecarboxylic acid, 6-chloro-, methyl ester,methyl 6-chloropyridine-2-carboxylate,6-chloro-2-picolinic acid methyl ester,METHYL 6-CHLORO-2-PYRIDINECARBOXYLATE

Methyl 6-Chloropyridine-2-carboxylate, 97+% METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE,AKOS BBS-00004651,6-CHLOROPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER,6-CHLORO-2-PICOLINIC ACID METHYL ESTER,6-Chloro-2-pyridinecarboxylic acid methyl ester,6-Chloropicolinic acid methyl ester,2-Pyridinecarboxylic acid, 6-chloro-, methyl ester,methyl 6-chloro-2-pyridinecarboxylate,methyl 2-(6-chloropyridin-2-yl)acetate,methyl 6-chloropicolinate,methyl (6-chloropyridin-2-yl)acetate,2-chloropyridine-6-carboxylate methyl,

6636-55-1

Picolinic acid series