H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH

Product Name: H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH
CAS No.: 199999-60-5
Chemical Name: H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH
Synonyms: WP9QY;TNF-α Antagonist;WP9QY, W9, YCWSQYLCY;TNF-ALPHA ANTAGONIST;WP9QY, TNF-a Antagonist - 1 mg;TUMOR NECROSIS FACTOR-ALPHA ANTAGONIST;H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH;161:PN:WO2010033207 SEQID:210 claimed protein;H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH, (Disulfide bond);H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH,(DISULFIDE BOND BETWEEN CYS2 AND CYS 8
CBNumber: CB4146920
Molecular Formula: C58H71N11O15S2
Formula Weight: 1226.38
MOL File: 199999-60-5.mol

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H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH Property

Boiling point:: 1692.1±65.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: -15°C
solubility: DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form: A crystalline solid
pka: 3.05±0.10(Predicted)
color: White to off-white
Water Solubility: water: 1mg/mL
5% acetic acid: 5mg/mL
Sequence: Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr (Disulfide bridge:Cys2-Cys8)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 654255
Product name: TNF-α Antagonist
Purity: The TNF-α Antagonist controls the biological activity of TNF-α.
Packaging: 1MG
Price: $341
Updated: 2025/07/31

Cayman Chemical

Product number: 17492
Product name: TNF-α Antagonist
Packaging: 500μg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 17492
Product name: TNF-α Antagonist
Packaging: 1mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 17492
Product name: TNF-α Antagonist
Packaging: 5mg
Price: $961
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: PEP0005218
Product name: H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH
Purity: 95.00%
Packaging: 5MG
Price: $495.77
Updated: 2021/12/16

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H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH Chemical Properties,Usage,Production

Uses

WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. (This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.)

Biological Activity

Cell permeable: no', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 5 μM as TNF-α antagonist

References

[1] Lin CC, et al. Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFalpha. Biomaterials. 2009 Oct;30(28):4907-14. DOI:10.1016/j.biomaterials.2009.05.083

H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH Suppliers

China 51 United States 6 Global 57

BOC Sciences

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199999-60-5, H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OHRelated Search:

HUWENTOXIN IV GIP (1-39) PHRIXOTOXIN 3 Angiotensin II, 5-L-isoleucine-8-glycine- antibacterial protein ll-37 amide (human) PKA Inhibitor Fragment (6-22) amide LCKLSL 2-8-Angiotensin II, 2-glycine-5-L-isoleucine- CALCIUM-LIKE PEPTIDE Dentonin DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS COG-1410 HNGF6A -Defensin-2 (human) (trifluoroacetate salt) L-Glutamine, L-leucyl-L-lysyl-L-lysyl-L-threonyl-L-α-glutamyl-L-threonyl- L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide C-PEPTIDE 2 (RAT) H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH

H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH

WP9QY

TUMOR NECROSIS FACTOR-ALPHA ANTAGONIST

TNF-ALPHA ANTAGONIST

H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH, (Disulfide bond)

H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH,(Disulfide bond between Cys2 and Cys 8

H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH,(DISULFIDE BOND BETWEEN CYS2 AND CYS 8

WP9QY, W9, YCWSQYLCY

TNF-α Antagonist

L-Tyrosine, L-tyrosyl-L-cysteinyl-L-tryptophyl-L-seryl-L-glutaminyl-L-tyrosyl-L-leucyl-L-cysteinyl-, cyclic (2→8)-disulfide

161:PN:WO2010033207 SEQID:210 claimed protein

WP9QY, TNF-a Antagonist - 1 mg

199999-60-5

C58H71N11O15S2