ChemicalBook > CAS DataBase List > 3-Chloro-4-fluoroaniline

3-Chloro-4-fluoroaniline

Product Name
3-Chloro-4-fluoroaniline
CAS No.
367-21-5
Chemical Name
3-Chloro-4-fluoroaniline
Synonyms
3-CHLORO-4-FLUORO-PHENYLAMINE;3-CHLORO-4-FLUOROBENZENAMINE;NSC 10290;3-Chloro-4-flu;AKOS BBS-00003577;Fluorochloroaniline;Chloro-4-fluoroanil;3-Chloro-4-fluoroani;Gefitinib Impurity K;Gefitinib IMpurity V
CBNumber
CB4182681
Molecular Formula
C6H5ClFN
Formula Weight
145.56
MOL File
367-21-5.mol
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3-Chloro-4-fluoroaniline Property

Melting point:
42-44 °C (lit.)
Boiling point:
227-228 °C (lit.)
Density 
1,226 g/cm3
bulk density
1000kg/m3
vapor pressure 
0.01 hPa (20 °C)
refractive index 
1,54-1,542
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
10g/l
pka
3.60±0.10(Predicted)
form 
Crystalline Solid
color 
Beige to brown
PH
7 (10g/l, H2O, 20℃)
Water Solubility 
10 g/L (20 ºC)
BRN 
1562786
Stability:
Stable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates. May be air-sensitive.
InChIKey
YSEMCVGMNUUNRK-UHFFFAOYSA-N
CAS DataBase Reference
367-21-5(CAS DataBase Reference)
EPA Substance Registry System
3-Chloro-4-fluoroaniline (367-21-5)
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Safety

Hazard Codes 
T,Xi,Xn
Risk Statements 
23/24/25-33-36/37/38-20/21/22
Safety Statements 
36/37/39-45-26
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
2
F 
9-23
Hazard Note 
Irritant/Toxic
TSCA 
T
HazardClass 
TOXIC
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214210
Toxicity
LD50 orally in Rabbit: 506 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
228583
Product name
3-Chloro-4-fluoroaniline
Purity
98%
Packaging
25g
Price
$26.8
Updated
2025/07/31
Sigma-Aldrich
Product number
8.18752
Product name
3-Chloro-4-fluoroaniline
Purity
for synthesis
Packaging
25g
Price
$77.6
Updated
2025/07/31
Sigma-Aldrich
Product number
228583
Product name
3-Chloro-4-fluoroaniline
Purity
98%
Packaging
100g
Price
$66.2
Updated
2025/07/31
Sigma-Aldrich
Product number
8.18752
Product name
3-Chloro-4-fluoroaniline
Purity
for synthesis
Packaging
100g
Price
$275
Updated
2023/01/07
TCI Chemical
Product number
C1024
Product name
3-Chloro-4-fluoroaniline
Purity
>98.0%(GC)
Packaging
25g
Price
$16
Updated
2025/07/31
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3-Chloro-4-fluoroaniline Chemical Properties,Usage,Production

Chemical Properties

dark purple to black solid

Uses

4-Fluoro-3-chloroaniline, is an organic Fluorinated building block used for the synthesis of pharmaceutical and biologically active compounds such as, novel 6-Fluorobenzothiazole-substituted pyrazole analogues, having antiinflammatory activity.

General Description

The exposure of workers to 3-chloro-4-fluoroaniline (CFA) was monitored by an HPLC method.

Synthesis

350-30-1

367-21-5

In a reaction vessel equipped with a mechanical stirrer and a reflux condenser tube, 0.83 mol of erbium chloride powder, 150 mL of an aqueous sodium bromide solution with a mass fraction of 22%, and 3-amino-3-(4-ethylphenyl)propionic acid with a mass fraction of 37% were added. The stirring speed was adjusted to 190 rpm and the reaction mixture was heated to 70 °C and maintained at this temperature for 130 minutes. Subsequently, 0.31 mol of 3-chloro-4-fluoronitrobenzene was slowly added dropwise for a controlled dropwise time of 110 minutes. After the dropwise addition was completed, the reaction temperature was raised to 85 °C and the reaction was refluxed for 4 hours. Upon completion of the reaction, 130 mL of aqueous potassium bisulfite solution with a mass fraction of 40% was added and then distilled under vacuum at 3.3 kPa to collect the 105-115 °C fraction. The resulting fraction was dissolved in 300 mL of 65% o-xylene solution, decolorized by molecular sieve and recrystallized in 87% mass fraction of 2-thiophene acetonitrile solution to finally obtain 41.49 g of 3-chloro-4-fluoroaniline in 92% yield.

References

[1] Catalysis Communications, 2010, vol. 11, # 5, p. 451 - 455
[2] RSC Advances, 2016, vol. 6, # 10, p. 7950 - 7954
[3] ACS Catalysis, 2015, vol. 5, # 8, p. 4814 - 4818
[4] Patent: , 2016, . Location in patent: Paragraph 0023; 0024; 0025
[5] Synthetic Communications, 2002, vol. 32, # 18, p. 2849 - 2853

3-Chloro-4-fluoroaniline Preparation Products And Raw materials

Raw materials

Potassium fluoride Ferric chloride Iron chloride hexahydrate Dimethyl sulfoxide 1,2-Dichlorobenzene

Preparation Products

Norfloxacin Ciprofloxacin hydrochloride 1,3-Dichloro-4-fluorobenzene Ciprofloxacin 2,4-Dichloro-5-fluorobenzoic acid 3-CHLORO-4-FLUOROPHENYL ISOTHIOCYANATE
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3-Chloro-4-fluoroaniline Suppliers

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View Lastest Price from 3-Chloro-4-fluoroaniline manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.
Product
3-Chloro-4-fluoroaniline 367-21-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
20tons
Release date
2025-10-24
Hebei Chuanghai Biotechnology Co., Ltd
Product
3-Chloro-4-fluoroaniline 367-21-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-08
Hebei Chuanghai Biotechnology Co,.LTD
Product
3-Chloro-4-Fluorobenzenamine 367-21-5
Price
US $10.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10 ton
Release date
2024-08-20

367-21-5, 3-Chloro-4-fluoroanilineRelated Search:

4-Chloroaniline 2-Chloroaniline 2-Fluoroaniline 3-Aminobenzotrifluoride 4-(Trifluoromethoxy)aniline 3-Fluoroaniline 3-Chloroaniline Chlorpropham 4-Fluoroaniline Epichlorohydrin 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol 3-chloro-4-nitrophenol 3-(3-morpholinylpropoxy)-4-methoxybenzonitrile Benzaldehyde, 2-amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]- O-Desmethyl Gefitinib 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 4-Defluoro-4-hydroxy Gefitinib Gefitinib Impurity 14

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