ChemicalBook > CAS DataBase List > 4-Aminobenzoic acid

4-Aminobenzoic acid

Product Name
4-Aminobenzoic acid
CAS No.
150-13-0
Chemical Name
4-Aminobenzoic acid
Synonyms
PABA;P-AMINOBENZOIC ACID;AMINOBENZOIC ACID;PARA AMINO BENZOIC ACID;4-Abz-OH;4-carboxyanilin;PARA-AMINOBENZOATE;Folic acid Impurity;4-Aminobenzoic acid CRS;4-Aminobenzoic Acid (USP)
CBNumber
CB4212038
Molecular Formula
C7H7NO2
Formula Weight
137.14
MOL File
150-13-0.mol
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4-Aminobenzoic acid Property

Melting point:
187-189 °C(lit.)
Boiling point:
251.96°C (rough estimate)
Density 
1.374 g/mL at 25 °C(lit.)
vapor pressure 
0Pa at 25℃
refractive index 
1.5323 (estimate)
Flash point:
250 °C
storage temp. 
2-8°C
solubility 
95% ethanol: soluble5%, clear to slightly hazy, colorless to yellow
form 
Crystalline Powder
pka
2.50, 4.87(at 25℃)
color 
White to light yellow
PH
3.5 (5g/l, H2O, 20℃)
Odor
Odorless
PH Range
3.5
Water Solubility 
4.7 g/L (20 ºC)
Sensitive 
Air & Light Sensitive
Merck 
14,423
BRN 
471605
Stability:
Stable. Incompatible with strong oxidizing agents. Combustible. Sensitive to light and air. May discolour on exposure to light.
InChIKey
ALYNCZNDIQEVRV-UHFFFAOYSA-N
LogP
0.96 at 25℃
CAS DataBase Reference
150-13-0(CAS DataBase Reference)
NIST Chemistry Reference
p-Aminobenzoic acid(150-13-0)
IARC
3 (Vol. 16, Sup 7) 1987
EPA Substance Registry System
p-Aminobenzoic acid (150-13-0)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-43
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
DG1400000
TSCA 
Yes
HS Code 
29224995
Hazardous Substances Data
150-13-0(Hazardous Substances Data)
Toxicity
LD50 in mice, rats (g/kg): 2.85, >6.0 orally (Scott, Robbins); LD50 in rabbits (g/kg): 2.0 i.v. (Richards); 1.83 orally (Cronheim)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.22312
Product name
4-Aminobenzoic acid
Purity
for synthesis
Packaging
250g
Price
$52.6
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22312
Product name
4-Aminobenzoic acid
Purity
for synthesis
Packaging
1kg
Price
$169
Updated
2024/03/01
Sigma-Aldrich
Product number
100536
Product name
4-Aminobenzoic acid
Purity
ReagentPlus , 99%
Packaging
1kg
Price
$158
Updated
2024/03/01
Sigma-Aldrich
Product number
01973
Product name
4-Aminobenzoic acid
Purity
analytical standard
Packaging
100mg
Price
$174
Updated
2024/03/01
TCI Chemical
Product number
A0269
Product name
4-Aminobenzoic Acid
Purity
>99.0%(HPLC)(T)
Packaging
25g
Price
$19
Updated
2024/03/01
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4-Aminobenzoic acid Chemical Properties,Usage,Production

Description

4-Aminobenzoic acid (also known as para-aminobenzoic acid or PABA because the number 4 carbon in the benzene ring is also known as the para position) is an organic compound with the formula H2NC6H4CO2H. PABA is a white solid, although commercial samples can appear gray. It is slightly soluble in water. It consists of a benzene ring substituted with amino and a carboxyl groups. The compound occurs naturally. The potassium salt is used as a drug against fibrotic skin disorders, such as Peyronie's disease, under the trade name Potaba. PABA is also occasionally used in pill form by sufferers of irritable bowel syndrome to treat its associated gastrointestinal symptoms, and in nutritional epidemiological studies to assess the completeness of 24-hour urine collection for the determination of urinary sodium, potassium, or nitrogen levels.

Chemical Properties

colorless needle-like crystals. turns light yellow in the air or in light. Soluble in hot water, ether, ethyl acetate, ethanol and glacial acetic acid, insoluble in water, benzene, and insoluble in petroleum ether.

Originator

Pabalate,Robins,US,1949

Uses

4-aminobenzoic acid is an aminobenzoic acid isomer that combines with pteridine and glutamic acid to folic acid. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in sunscreens. Also it is used as a component of some medicines e.g analgesic or anesthetic preparations sunscreen agents and bentiromide.

Definition

ChEBI: 4-aminobenzoic acid is an aminobenzoic acid in which the amino group is para to the carboxy group. It has a role as an Escherichia coli metabolite, a plant metabolite and an allergen. It derives from a benzoic acid. It is a conjugate acid of a 4-aminobenzoate.

Preparation

4-Aminobenzoic acid synthesis method: add 38.0g of p-nitrobenzoic acid, 200mL of water, 20mL of tetrahydrofuran, 0.4g of sodium dodecyl sulfonate and 1.9g of Raney nickel to the autoclave, nitrogen replacement Three times, fill with hydrogen, adjust the pressure to 0.9±0.1MPa, adjust the temperature to 100±2°C, and keep the reaction under pressure for 4h to complete. After the reaction, the catalyst was recovered by filtration, left to stand for stratification, the water layer was directly applied mechanically, the tetrahydrofuran layer was distilled and recovered and applied mechanically, then 1.5 g of activated carbon was added to the 4-aminobenzoic acid mother liquor, and under nitrogen protection, heating and refluxing for decolorization for 20min, Filtration, cooling and crystallization of mother liquor, filtration, drying under vacuum at 80-85 °C to obtain 30.3 g of 4-aminobenzoic acid with a yield of 97.2%, a melting point of 187.1-187.6 °C, and a content of 100.2% (permanent stop titration method) .

brand name

RVPaba Lipstick (ICN).

Therapeutic Function

Sunscreen agent, Antirickettsial

Biological Functions

4-Aminobenzoic acid is one of the most important aromatic amino acids. It is an important part of the substances necessary for the growth and division of body cells. It has an irreplaceable role in the metabolism of life. It is used in yeast, liver, bran and malt. The content is very high. 4-Aminobenzoic acid can relieve anemia caused by lack of red blood cells, viral anemia, sprue and anemia during pregnancy. 4-Aminobenzoic acid is a high-efficiency nutritional product with the main ingredient - vitamin B-100, which can effectively improve the three major metabolisms of the human body, comprehensively combat fatigue and relieve stress. The compatibility of 4-aminobenzoic acid with penicillin or streptomycin can effectively improve the bacteriostatic effect.

Synthesis Reference(s)

Synthesis, p. 285, 1971
Tetrahedron, 47, p. 8587, 1991 DOI: 10.1016/S0040-4020(01)82402-9

General Description

Colorless crystals that discolor on exposure to light and air.

Reactivity Profile

4-Aminobenzoic acid is incompatible with ferric salts and oxidizing agents.

Hazard

Questionable carcinogen.

Flammability and Explosibility

Non flammable

Safety Profile

Moderately toxic by ingestion and intravenous routes. Ingesting large doses can cause nausea, vomiting, skin rash, methemoglobinemia, and possibly toxic hepatitis. Experimental reproductive effects. Mutation data reported. Questionable carcinogen. Combustible. When heated to decomposition it emits toxic fumes of NO,. A topical sunscreen.

Purification Methods

Purify p-aminobenzoic acid by dissolving it in 4-5% aqueous HCl at 50-60o, decolorising with charcoal and carefully precipitating it with 30% Na2CO3 to pH 3.5-4 in the presence of ascorbic acid. It can be recrystallised from water, EtOH or EtOH/water mixtures. [Beilstein 14 IV 1126.]

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View Lastest Price from 4-Aminobenzoic acid manufacturers

Hebei Dangtong Import and export Co LTD
Product
4-Aminobenzoic acid 150-13-0
Price
US $100.00-90.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20Tons
Release date
2023-10-09
Henan Fengda Chemical Co., Ltd
Product
4-Aminobenzoic acid 150-13-0
Price
US $50.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-22
Sigma Audley
Product
4-Aminobenzoic acid 150-13-0
Price
US $35.00-25.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
200tons/year
Release date
2024-03-12

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