ChemicalBook > CAS DataBase List > 2-Chloro-3-pyridinecarboxaldehyde
2-Chloro-3-pyridinecarboxaldehyde
- Product Name
- 2-Chloro-3-pyridinecarboxaldehyde
- CAS No.
- 36404-88-3
- Chemical Name
- 2-Chloro-3-pyridinecarboxaldehyde
- Synonyms
- 2-CHLORONICOTINALDEHYDE;2-CHLORO-3-FORMYLPYRIDINE;SKL1445;2-Chloronicotinal;TIMTEC-BB SBB004156;2-Chloro-3-pyridinec;oro-3-pyridinecarboxaL;CHLORO-2-FORMYL-3-PYRIDINE;Chloro-3-pyridinecarboxaldeh;2-Chloronicotinaldehyde ,97%
- CBNumber
- CB4221766
- Molecular Formula
- C6H4ClNO
- Formula Weight
- 141.56
- MOL File
- 36404-88-3.mol
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2-Chloro-3-pyridinecarboxaldehyde Property
- Melting point:
- 50-54 °C (lit.)
- Boiling point:
- 119 °C(Press: 30 Torr)
- Density
- 1.332±0.06 g/cm3(Predicted)
- Flash point:
- >230 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, DMSO
- form
- Powder or Low Melting Solid
- pka
- -1.36±0.10(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C6H4ClNO/c7-6-5(4-9)2-1-3-8-6/h1-4H
- InChIKey
- KHPAGGHFIDLUMB-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1C=O
- CAS DataBase Reference
- 36404-88-3(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 632155
- Product name
- 2-Chloro-3-pyridinecarboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $40.1
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 632155
- Product name
- 2-Chloro-3-pyridinecarboxaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $71.1
- Updated
- 2023/06/20
TCI Chemical
- Product number
- C2487
- Product name
- 2-Chloro-3-pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $20
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C2487
- Product name
- 2-Chloro-3-pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $80
- Updated
- 2025/07/31
TRC
- Product number
- C369570
- Product name
- 2-Chloronicotinaldehyde
- Packaging
- 50g
- Price
- $690
- Updated
- 2021/12/16
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2-Chloro-3-pyridinecarboxaldehyde Chemical Properties,Usage,Production
Chemical Properties
Brown Solid
Uses
Starting material for the preparation of 5-azaindoles by the Hemetsberger-Knittel reaction involving the thermal decomposition of alkenyl azides.1
Uses
Azaindazole intermediate.
Synthesis
42330-59-6
36404-88-3
General procedure for the synthesis of 2-chloro-3-pyridinecarboxaldehyde from 2-chloro-3-pyridinemethanol: The hydrolyzed product was transferred to a four-necked flask, 300 g of ethyl acetate and 0.8 g of TEMPO were added, and the mixture was stirred and cooled to 0 °C. Subsequently, 450 g of freshly prepared sodium hypochlorite solution (pH=11, 10% active chlorine) was slowly added dropwise, and the reaction temperature was controlled at 0-5 °C. After the dropwise addition, the reaction system was warmed up to room temperature and stirred continuously for 1 hour to ensure complete reaction. Post-treatment steps: the reaction mixture was allowed to stand and layered, the ethyl acetate phase was separated, washed with water, dried with anhydrous magnesium sulfate, concentrated and then cooled and crystallized to give 79 g of the light yellow crystalline product 2-chloro-3-pyridinecarboxaldehyde, with a purity of 98.2%, and based on the yield of 2-chloro-3-chloromethylpyridine was 89.6%.
References
[1] Patent: CN107501171, 2017, A. Location in patent: Paragraph 0028; 0034; 0035; 0036; 0037; 0044; 0045-0047
[2] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 5, p. 1595 - 1597
[3] Synthetic Communications, 2008, vol. 38, # 6, p. 889 - 904
[4] Synthesis, 2010, # 20, p. 3439 - 3448
[5] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 5, p. 694 - 707
2-Chloro-3-pyridinecarboxaldehyde Preparation Products And Raw materials
Raw materials
Hexane
Ammonium hydroxide
Nitrogen
N,N-Dimethylformamide
Sodium sulfate
Sodium chloride
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone
Sodium
Triethylamine
Diisopropylamine
Tetrahydrofuran
Ammonium chloride
Ethyl acetate
Hydrochloric acid
Magnesium sulfate
n-Butyllithium
2-Chloropyridine
Preparation Products
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View Lastest Price from 2-Chloro-3-pyridinecarboxaldehyde manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- 2-Chloro-3-pyridinecarboxaldehyde 36404-88-3
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 100KG
- Release date
- 2025-08-20
Hebei Chuanghai Biotechnology Co,.LTD
- Product
- 2-Chloro-3-pyridinecarboxaldehyde 36404-88-3
- Price
- US $500.00-200.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-21
Jiangsu Magic Biotechnology Co., Ltd
- Product
- 2-Chloropyridine- 3-carbaldehyde 36404-88-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2023-05-04
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