Chlorotrimethylsilane
- Product Name
- Chlorotrimethylsilane
- CAS No.
- 75-77-4
- Chemical Name
- Chlorotrimethylsilane
- Synonyms
- TMSCL;75-77-4;CSI;TMCS;TRIMETHYLSILYL CHLORIDE;TRIMETHYLCHLOROSILANE;(CH3)3SiCl;Trimethyl monochlorosilane;Chlorotrimethysilane;Trimethylchlorosilicane
- CBNumber
- CB4375627
- Molecular Formula
- C3H9ClSi
- Formula Weight
- 108.64
- MOL File
- 75-77-4.mol
Chlorotrimethylsilane Property
- Melting point:
- −40 °C(lit.)
- Boiling point:
- 57 °C(lit.)
- Density
- 0.857 g/mL at 25 °C
- vapor density
- 3.7 (vs air)
- vapor pressure
- 100 mm Hg ( 25 °C)
- refractive index
- n20/D 1.500
- Flash point:
- 104 °F
- storage temp.
- Store below +30°C.
- solubility
- Miscible with ether, benzene, diethylether and perchloroethylene.
- form
- Liquid
- Specific Gravity
- 0.8536 (27℃)
- color
- Clear colorless
- explosive limit
- 1.5-46%(V)
- Water Solubility
- REACTS
- Sensitive
- Moisture Sensitive
- Hydrolytic Sensitivity
- 8: reacts rapidly with moisture, water, protic solvents
- BRN
- 1209232
- Stability:
- Stable. Highly flammable - note low flash point. Reacts violently with water. Incompatible with water, moisture, strong oxidizing agents, strong acids, strong bases, aldehydes, alcohols, amines, esters, ketones.
- InChIKey
- IJOOHPMOJXWVHK-UHFFFAOYSA-N
- CAS DataBase Reference
- 75-77-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Silane, chlorotrimethyl-(75-77-4)
- EPA Substance Registry System
- Trimethylchlorosilane (75-77-4)
Safety
- Hazard Codes
- T,F,C,Xn
- Risk Statements
- 20/21-36/38-34-21-14-11-37-35-19-40-10-67-20/21/22-52
- Safety Statements
- 26-36/37/39-45-16-36/37-7/9
- RIDADR
- UN 2924 3/PG 2
- WGK Germany
- 2
- RTECS
- VV2710000
- F
- 10-21
- Autoignition Temperature
- 752 °F
- Hazard Note
- Highly Flammable/Corrosive/Moisture Sensitive
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29310095
- Hazardous Substances Data
- 75-77-4(Hazardous Substances Data)
- Toxicity
- LD50 orally in Rabbit: 4868 mg/kg LD50 dermal Rabbit 1530 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 95541
- Product name
- Chlorotrimethylsilane
- Purity
- produced by Wacker Chemie AG, Burghausen, Germany, ≥99.0% (GC)
- Packaging
- 500G
- Price
- $84.6
- Updated
- 2024/03/01
- Product number
- 95541
- Product name
- Chlorotrimethylsilane
- Purity
- produced by Wacker Chemie AG, Burghausen, Germany, ≥99.0% (GC)
- Packaging
- 25KG
- Price
- $2320
- Updated
- 2024/03/01
- Product number
- 89595
- Product name
- Chlorotrimethylsilane
- Purity
- for GC derivatization, LiChropur?, ≥99.0% (GC)
- Packaging
- 50ML
- Price
- $70.9
- Updated
- 2024/03/01
- Product number
- 8.18737
- Product name
- Chlorotrimethylsilane
- Purity
- for synthesis
- Packaging
- 100mL
- Price
- $54.8
- Updated
- 2024/03/01
- Product number
- 8.18737
- Product name
- Chlorotrimethylsilane
- Purity
- for synthesis
- Packaging
- 500mL
- Price
- $168
- Updated
- 2024/03/01
Chlorotrimethylsilane Chemical Properties,Usage,Production
Description
Chlorotrimethylsilane is a valuable reagent for the protection of the hydroxyl function in organic synthesis. It should be distilled from calciumhydride (or tributylamine) under nitrogen before use,and stored and weighed under nitrogen. Use of the reagent without purification has been reported to lead to explosions. Chlorotrimethylsilane may contain dichlorodimethylsilane as an impurity. This may be removed before distillation by very cautious treatment with a small amount of water，which hydrolyses the dichloro compound more rapidly. Excess chlorotrimethylsilane in a reaction mixture may be destroyed by the very careful addition of aqueous sodium hydrogencarbonate solution.
Chemical Properties
Trimethylchlorosilane is a colorless fuming liquid with a pungent odor. Readily hydrolyzed with liberation of hydrogen chloride; soluble in benzene, ether and perchloroethylene. Chlorotrimethylsilane is a chloro-organosilane compound mainly used for silylation reactions.
Uses
Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis. It is used in the production of trimethylsilyl halides, pseudohalides and various organic silicon compounds. It is also used to produce hexamethyldisilane by reduction.
Application
Trimethylsilyl chloride(TMCS) is the most extensively used derivatization reagent for gas chromatography.The reactions are generally performed under anhydrous conditions although reactions can be performed on samples obtained from water-containing samples.There are considerable opportunities for artifacts stemming from a variety of reasons including off-target reactions with aldehydes and ketones.The rate of reaction of TMCS with nucleophilic targets is comparatively slow compared to other alkylsilyl chlorides and requires the presence of a base catalyst such as pyridine.TMCS is included as a catalyst with other trialkylsilyl reagent such N,O-bis- (trimethylsilyl)trifluroacetamide (BSA) or N-methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA).The order of functional group reactivity is alcohols>phenols>carboxylic acids>amines>amides.
Reactions
Related to the epoxide ring opening, TMSCl also mediates some cyclopropane ring opening reactions. For example, treatment of 1-aceto-2,2-dimethylcyclopropane with TMSCl and sodium chloride in acetonitrile at 55°C for 24 h generated 5-chloro-5-methyl-2-hexanone in 84% yield (eq 39).When sodium iodide was employed to replace sodium chloride, iodotrimethylsilane generated in situ, and the reaction completed under more facile conditions (rt and 12 h). Interestingly, the dominant product is 5-iodo-4,4-dimethyl-2-pentanone (eq 40), arising from iodide attacking at the less hindered secondary methylene carbon, instead of the quaternary dimethylmethylene carbon.
Definition
ChEBI: Chlorotrimethylsilane is a silyl chloride consisting of a central silicon atom covalently bound to one chloro and three methyl groups. Chlorotrimethylsilane is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.
General Description
Trimethylchlorosilane appears as a colorless fuming liquid with a pungent odor. Boiling point 135° F, Flash point -18°F. Density 0.854g/cm3. The vapor and liquid may cause burns. Vapors are heavier than air.
Reactivity Profile
Chlorotrimethylsilane reacts vigorously and exothermically with water to produce hydrogen chloride.
Health Hazard
Similar to other silanes. Toxicity is rated high for inhalation, ingestion and local irritation. May cause death or permanent injury after a very short exposure to small quantities.
Fire Hazard
Violent reaction with water. Toxic and irritating hydrogen chloride and phosgene may be formed in fires. Difficult to extinguish, re-ignition may occur. Flashback along vapor trail may occur. Containers may explode in fire. Vapor may explode if ignited in enclosed area. When heated to decomposition or on contact with acids or acid fumes, chloride fumes are emitted. Reacts with surface moisture, releasing hydrogen chloride, which will corrode common metals and form flammable hydrogen gas. Avoid contact with water; Chlorotrimethylsilane readily hydrolyzes, liberating hydrochloric acid. Hazardous polymerization may not occur.
Safety Profile
Poison by ingestion and skin contact. Moderately toxic by inhalation and intraperitoneal routes. A corrosive irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. A flammable liquid and very dangerous fire hazard when exposed to heat or flame. Violent reaction with water or hexafluoroisopropylideneamino lithium, A preparative hazard. To fight fire, use foam, alcohol foam, fog. When heated to decomposition it emits toxic fumes of Cl-. An intermediate in the production of silicones. See also CHLOROSILASES.
Potential Exposure
Trimethylchlorosilane is used as an intermediate to make silicone products, including lubricants
Shipping
UN1298 Trimethylchlorosilane, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material.
Purification Methods
Likely impurities are other chlorinated methylsilanes and tetrachlorosilane (b 57.6o), some of which can form azeotropes. To avoid the latter, very efficient fractional distillation is required. It has been fractionated through a 12 plate glass helices-packed column with only the heart-cut material being used. It has also been fractionated through a 90cm, 19mm diameter Stedman column (p 11). Purify it by redistilling from CaH2 before use. [Sauer et al. J Am Chem Soc 70, 4254 1948, Sauer & Hadsell J Am Chem Soc 70 4258 1948, Langer et al. J Org Chem 23 50 1958, Beilstein 4 IV 4007.] FLAMMABLE and CORROSIVE.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Chlorosilanes react vigorously with bases and both organic and inorganic acids generating toxic and/or flammable gases. Chlorosilanes react with water, moist air, or steam to produce heat and toxic, corrosive fumes of hydrogen chloride. They may also produce flammable gaseous hydrogen. Attacks metals in the presence of moisture. Vigorous reaction with aluminum powder.
Waste Disposal
Do not discharge into drains or sewers. Use a licensed disposal contractor to an approved landfill. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office for guidance on acceptable disposal practices. The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material’s impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
Chlorotrimethylsilane Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Chlorotrimethylsilane manufacturers
- Product
- Trimethylchlorosilane 75-77-4
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100 tons
- Release date
- 2022-09-23
- Product
- Cholrotrimethyylsilane 75-77-4
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99.96%
- Supply Ability
- 500ton
- Release date
- 2023-07-03
- Product
- Chlorotrimethylsilane 75-77-4
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000KG
- Release date
- 2023-08-30