ChemicalBook > CAS DataBase List > 6-Chloronicotinic acid

6-Chloronicotinic acid

Product Name
6-Chloronicotinic acid
CAS No.
5326-23-8
Chemical Name
6-Chloronicotinic acid
Synonyms
2－chloro－5－pyrdinecarboxylic acid;6-CHLOROPYRIDINE-3-CARBOXYLIC ACID;2-chloropyridine-5-carboxylic acid;6-ChL;6-Chloronicoti;TIMTEC-BB SBB004004;RARECHEM AL BO 0729;6 - chlorine niacin;6-Chloronicotinic ac;2-Chloroncotinic acid
CBNumber
CB4707499
Molecular Formula
C6H4ClNO2
Formula Weight
157.55
MOL File
5326-23-8.mol
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6-Chloronicotinic acid Property

Melting point:
190 °C (dec.)(lit.)
Boiling point:
241.15°C (rough estimate)
Density 
0.5
refractive index 
1.5870 (estimate)
Flash point:
192°C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
deionized water: soluble
form 
Crystalline Powder
pka
3.24±0.10(Predicted)
color 
Off-white to beige
Water Solubility 
Soluble in water (2 mg/ml at 20°C), ethanol, methanol, DMSO, and slightly soluble in chloroform.
Decomposition 
192 ºC
BRN 
115993
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
UAWMVMPAYRWUFX-UHFFFAOYSA-N
CAS DataBase Reference
5326-23-8(CAS DataBase Reference)
NIST Chemistry Reference
6-Chloronicotinic acid(5326-23-8)
EPA Substance Registry System
6-Chloronicotinic acid (5326-23-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25-37/39
WGK Germany 
3
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
156353
Product name
6-Chloropyridine-3-carboxylic acid
Purity
99%
Packaging
5g
Price
$45.7
Updated
2024/03/01
Sigma-Aldrich
Product number
156353
Product name
6-Chloropyridine-3-carboxylic acid
Purity
99%
Packaging
25g
Price
$57.4
Updated
2024/03/01
TCI Chemical
Product number
C1116
Product name
6-Chloronicotinic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$92
Updated
2024/03/01
TCI Chemical
Product number
C1116
Product name
6-Chloronicotinic Acid
Purity
>98.0%(T)
Packaging
100g
Price
$274
Updated
2024/03/01
Alfa Aesar
Product number
A15620
Product name
6-Chloronicotinic acid, 99%
Packaging
5g
Price
$35.65
Updated
2024/03/01
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6-Chloronicotinic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white to beige crystalline powder

Uses

6-Chloronicotinic acid is used as building block for different chemical synthesis. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors.

Uses

6-Chloropyridine-3-carboxylic acid (6-chloronicotinic acid/6-CNA) has been used to study its photolytic and photocatalytic degradation. 6-CNA is a degradation product of neonicotinoid insecticides imidacloprid and acetamiprid and is known to appear in different environmental matrices. The product has been used as a media component during the isolation of 6-CNA degrading bacterial strain from imidacloprid-exposed soil samples.

Definition

ChEBI: 6-Chloronicotinic acid is a member of pyridines and an aromatic carboxylic acid.

General Description

6-Chloropyridine-3-carboxylic acid is a metabolite of the neonicotinoid pesticides, imidacloprid and acetamiprid and occurs in different environmental matrices.(3) It is widely used in agricultural crop protection, domestic insect control and environmental pest management.

Synthesis

In a 1000ml flask, add 450g chlorobenzene, 100g 2-chloro-5-methylpyridine, and 3g catalyst cobalt acetate under stirring, heat the system to 80℃, introduce oxygen, and control the oxygen flow rate at 0.4L/min. React under this condition for 4 hours. After the reaction, cool the system to room temperature, filter, and dry to obtain a mixture of 119g 6-chloronicotinic acid and cobalt acetate. Place those mentioned above mixed crude product in a 1000ml flask, add 600g of recrystallization solvent methanol, stir and heat to reflux; wait for the 6-chloronicotinic acid crude product to dissolve completely, keep warm for 5min, slowly cool the system to 5℃, precipitate a white product, maintain this internal temperature and continue stirring for 1 hour, filter, wash the filter cake once with a small amount of cooled methanol, and dry the obtained damp product at 80℃ for 4 hours to obtain 98.5g 6-chloronicotinic acid, purity 99.52% (HPLC), yield 79.7%.

Purification Methods

Purify it by recrystallisation from hot H2O and sublime it in a vacuum. [Pechmann & Welsch Chem Ber 17 2384 1884, Herz & Murty J Org Chem 26 122 1961, Beilstein 22/2 V 177.]

6-Chloronicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

TERT-BUTYL 4-(5-FORMYLPYRID-2-YL)PIPERAZINE-1-CARBOXYLATE 6-MORPHOLINONICOTINOYL CHLORIDE 6-MORPHOLINONICOTINIC ACID 2-chloro-5-cyanopyridine 6-PHENOXYNICOTINIC ACID 6-PHENOXYNICOTINONITRILE 6-PHENOXYNICOTINOYL CHLORIDE
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6-Chloronicotinic acid Suppliers

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View Lastest Price from 6-Chloronicotinic acid manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
6-Chloronicotinic acid 5326-23-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-22
Hebei Chuanghai Biotechnology Co,.LTD
Product
6-Chloronicotinic Acid 5326-23-8
Price
US $10.70/kg
Min. Order
10kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-20
Henan Fengda Chemical Co., Ltd
Product
6-Chloronicotinic acid 5326-23-8
Price
US $8.00-0.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-22

5326-23-8, 6-Chloronicotinic acidRelated Search:

Isonicotinic acid Ethyl 2-(Chlorosulfonyl)acetate Xanthinol nicotinate Inositol nicotinate 2-Hydroxy-5-pyridinecarboxylic acid 2,6-Dichloro-5-fluoronicotinic acid 3,4,5-Trifluorobenzaldehyde 5,6-Dichloronicotinic acid 6-CHLORO-4-ETHOXYNICOTINIC ACID Ethyl 4,6-dichloronicotinate 2,6-Dichloronicotinic acid 6-Chloronicotinic acid methyl ester C7H6ClNO2,6-CHLORONICOTINIC ACID METHYL ESTER Difluorochloromethane 4,6-Dichloronicotinic acid 2-Amino-5-chloropyridine-3-carboxylic acid 5-BROMO-6-CHLORONICOTINIC ACID METHYL ESTER Ethyl 6-chloronicotinate METHYL 5,6-DICHLORONICOTINATE

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