ChemicalBook > CAS DataBase List > SR-717

SR-717

Product Name
SR-717
CAS No.
2375421-09-1
Chemical Name
SR-717
Synonyms
SR171;SR-717;SR-717 lithium;SR171&SR-717 lithium;SR 717 (lithium salt);SR-717, 10 mM in DMSO;4,5-difluoro-2-[(6-imidazol-1-ylpyridazine-3-carbonyl)amino]benzoate;Lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate;immunity,MPYS,MITA,inhibit,ISG-THP1,Inhibitor,SR 717,mimetic,TMEM173,STING,SR717,cGAMP,THP1,antitumor,ERIS,SR-717,PD-L1,Stimulator of Interferon Genes
CBNumber
CB47247714
Molecular Formula
C15H10F2LiN5O3
Formula Weight
353.21
MOL File
2375421-09-1.mol
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SR-717 Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in DMSO (>25 mg/ml)
form 
solid
color 
Off-white
Water Solubility 
Water: < 0.1 mg/mL (insoluble)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.
InChI
InChI=1S/C15H9F2N5O3.Li.H/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22;;/h1-7H,(H,19,23)(H,24,25);;
InChIKey
FTILLHFNTUUQIF-UHFFFAOYSA-N
SMILES
N(C1C=C(F)C(F)=CC=1C(=O)O)C(C1N=NC(N2C=NC=C2)=CC=1)=O.[LiH]
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

ChemScene
Product number
CS-0135108
Product name
SR-717
Purity
99.75%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0135108
Product name
SR-717
Purity
99.75%
Packaging
10mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0135108
Product name
SR-717
Purity
99.75%
Packaging
25mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0135108
Product name
SR-717
Purity
99.75%
Packaging
50mg
Price
$650
Updated
2021/12/16
ChemScene
Product number
CS-0135108
Product name
SR-717
Purity
99.75%
Packaging
100mg
Price
$950
Updated
2021/12/16
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SR-717 Chemical Properties,Usage,Production

Description

SR-717 (2375421-09-1) is a cell permeable and exceptionally selective STING agonist (IC50 = 7.8 μM).? It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMC’s.

Uses

SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity[1].

in vivo

SR-717 (30 mg/kg intraperitoneal once-per-day for 1 week) shows antitumor activities in WT or Stinggt/gt mice[1].
SR-717 (30 mg/kg intraperitoneally for 7 days) displays antitumor activity; promots the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming[1].

Animal Model:WT or Stinggt/gt mice[1]
Dosage:30 mg/kg
Administration:Intraperitoneally; once-per-day for 1 week
Result:Maximally inhibited tumor growth.

References

[1] EMILY N. CHIN. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic[J]. Science, 2020, 369 6506. DOI:10.1126/science.abb4255

SR-717 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR-717 Suppliers

China 65 United States 7 USA 1 Global 73
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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United States
ProdList
32435
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Focus Biomolecules
Tel
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Fax
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Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
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58
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

2375421-09-1, SR-717Related Search:

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  • SR-717
  • SR171
  • SR-717 lithium
  • SR 717 (lithium salt)
  • immunity,MPYS,MITA,inhibit,ISG-THP1,Inhibitor,SR 717,mimetic,TMEM173,STING,SR717,cGAMP,THP1,antitumor,ERIS,SR-717,PD-L1,Stimulator of Interferon Genes
  • Lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate
  • SR171&SR-717 lithium
  • SR-717, 10 mM in DMSO
  • 4,5-difluoro-2-[(6-imidazol-1-ylpyridazine-3-carbonyl)amino]benzoate
  • 2375421-09-1
  • C15H8F2LiN5O3