ChemicalBook > CAS DataBase List > Benzylamine

Benzylamine

Product Name
Benzylamine
CAS No.
100-46-9
Chemical Name
Benzylamine
Synonyms
BZA;BENZENEMETHANAMINE;Moringine;Benzylamin;N-BENZYLAMINE;Benzenethanamine;PHENYLMETHYLAMINE;omega-Aminotoluene;sumine2006;sumine2005
CBNumber
CB4852584
Molecular Formula
C7H9N
Formula Weight
107.15
MOL File
100-46-9.mol
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Benzylamine Property

Melting point:
10 °C (lit.)
Boiling point:
184-185 °C (lit.)
Density 
0.981 g/mL at 25 °C (lit.)
vapor pressure 
1.2 hPa (20 °C)
refractive index 
n20/D 1.543(lit.)
Flash point:
140 °F
storage temp. 
Store below +30°C.
solubility 
alcohol: miscible
form 
Liquid
pka
9.33(at 25℃)
color 
Clear colorless to slightly yellow
PH
11.4 (100g/l, H2O, 20℃)
Odor
Strong ammonia.
explosive limit
0.7-8.2%(V)
Water Solubility 
soluble
Sensitive 
Air Sensitive
Merck 
14,1125
BRN 
741984
Dielectric constant
4.6（Ambient）
Stability:
Combustible. Incompatible with strong oxidizing agents, strong acids.
InChIKey
WGQKYBSKWIADBV-UHFFFAOYSA-N
LogP
1 at 25℃
CAS DataBase Reference
100-46-9(CAS DataBase Reference)
NIST Chemistry Reference
Benzylamine(100-46-9)
EPA Substance Registry System
Benzylamine (100-46-9)
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Safety

Hazard Codes 
C
Risk Statements 
21/22-34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2735 8/PG 2
WGK Germany 
1
RTECS 
DP1488500
F 
34
Autoignition Temperature
405 °C
TSCA 
Yes
HS Code 
2921 49 00
HazardClass 
8
PackingGroup 
II
Hazardous Substances Data
100-46-9(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 552 mg/kg LD50 dermal Rat 1350 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.01812
Product name
Benzylamine
Purity
for synthesis
Packaging
100mL
Price
$42.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01812
Product name
Benzylamine
Purity
for synthesis
Packaging
500mL
Price
$81.6
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01812
Product name
Benzylamine
Purity
for synthesis
Packaging
1L
Price
$124
Updated
2024/03/01
Sigma-Aldrich
Product number
13180
Product name
Benzylamine
Purity
for GC derivatization, ≥99.0%
Packaging
100ml
Price
$41.6
Updated
2024/03/01
TCI Chemical
Product number
B0406
Product name
Benzylamine
Purity
>99.0%(GC)
Packaging
25mL
Price
$26
Updated
2024/03/01
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Benzylamine Chemical Properties,Usage,Production

Chemical Properties

colourless liquid with an ammoniacal odour

Uses

Benzylamine is used as a chemical intermediate for dyes, pharmaceuticals, and polymers.It is also employed as a corrosion inhibitor and as a brightener in electroplating baths. It also finds use in the manufacture of explosives.

Uses

Benzylamine is a valuable intermediate for various applications and a building block for chemical synthesis used in pharmaceuticals and crop protection agents. It finds application in the coating industry. It is involved as a carrier electrolyte for separation of alkali, alkaline earth and ammonium cations in water samples by capillary electrophoresis with indirect UV detection. It is also used in synthesis of cross-linked porous copolymer supports based on N-(p-vinylbenzoyl)-2-methylalanine, styrene and divinylbenzene. In the textile industry, it is used in colored dyes. It is often used for medicinal purposes in topical creams and antifungal solutions as well as in vitamins.

Uses

Benzylamine may be used as a derivatization agent to increase the sensitivity of 5-hydroxyindoles, catecholamines and catechols in biological samples prior to their determination using high performance liquid chromatography (HPLC) coupled with fluorescence detection.

Preparation

28% Aqueous Ammonia, 810g
Benzyl chloride, 84.3g
49% Aqueous NaOH, 52.3g
Diethyl Ether, 200g
A three-necked flask was equipped with a reflux condenser dropping funnel and an agitator. All of the aqueous ammonium hydroxide solution was poured into the flask, then the benzyl chloride was introduced drop by drop; over a period of two hours with constant stirring of the mixture. The exothermic heat of reaction kept the temperature between 30-34°C during this period. When it is desired to introduce the benzyl chloride at a faster rate, conventional cooling means can be employed to control the temperature. A large excess of ammonia was employed as the molar ratio of reactants was 20:1. An additional two hours was allowed to insure completion of the following reaction:

Then the equimolecular quantity of caustic soda solution was added. When quiescent, the mixture split into an aqueous layer and an oily layer. After separating these two layers by use of a separatory funnel, the aqueous phase was made available for further repeated use by merely adding sufficient ammonium hydroxide to bring the total quantity of ammonia up to the original figure. The oily layer was steam distilled until no further oily constituent was visible in the condensed distillate as it dripped down the condenser tube. This distillate was saturated with sodium chloride and successively extracted with an initial 80 and three 40 gram batches of ethyl ether. Upon evaporation of the ether from the extract, 52g of crude benzylamine remain which was distilled at atmospheric pressure. 41g grams of substantially pure benzylamine distilled over in the boiling range 185-192°C, while the residue was found to contain an additional 2.3g of benzylamine and 8.7g of other matter which was believed to consist entirely of dibenzyl amine. Thus the total yield of benzylamine was 43.3g or 60.7% based on the weight of benzyl chloride.

Definition

ChEBI: A primary amine compound having benzyl as the N-substituent. It has been isolated from Moringa oleifera (horseradish tree).

Synthesis Reference(s)

Synthetic Communications, 25, p. 863, 1995 DOI: 10.1080/00397919508013422
Synthesis, p. 48, 1987 DOI: 10.1055/s-1987-27838

General Description

Colorless to light yellow liquid with a strong odor of ammonia. Floats and mixes with water.

Air & Water Reactions

Water soluble.

Reactivity Profile

In presence of moisture, Benzylamine may weakly corrode some metals. Liquid will attack some plastics [USCG, 1999]. Neutralize acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

Hazard

Highly toxic, strong irritant to skin and mucous membranes.

Health Hazard

Inhalation of vapor causes irritation of the mucous membranes of the nose and throat, and lung irritation with respiratory distress and cough. Headache, nausea, faintness, and anxiety can occur. Exposure to vapor produces eye irritation with lachrymation, conjunctivitis, and corneal edema resulting in halos around lights. Direct local contact with liquid is known to produce severe and sometimes permanent eye damage and skin burns. Vapors may also produce primary skin irritation and dermatitis.

Fire Hazard

Special Hazards of Combustion Products: Toxic nitrogen oxides may form in a fire.

Flammability and Explosibility

Non flammable

Chemical Reactivity

Reactivity with Water: No reaction; Reactivity with Common Materials: In presence of moisture may severely corrode some metals. In liquid state this chemical will attack some plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Toxicology

Benzylamine is readily biodegradable. It is harmful in aquatic environment [German class for hazards in aquatic environment: 1 (weak effect) (WGK 1)].Acute toxicity: Pseudomonas fluorescens (bacteria) 500 mg (EC0); Scenedesmus quadricauda (algae) 6 mg (96-h EC10); Daphnia magna 60 mg (48-h EC50); Leuciscus idus (fish) 20 mg (48-h EC0); Pimephals promelas (fish) 102 mg (96-h EC50).Benzylamine is Ames test negative (no mutagenic effect). Acute oral toxicity: LD50 1130 mg/kg (rat). Acute percutaneous toxicity: LD50 1340 mg/kg (rat). Toxicity class 3 (Switzerland). All rats inhaling benzylamine for 3 h survived a two-week period (full body exposure). After full body exposure for 5h, 17 % died.

storage

Benzylamine is slowly oxidized on contact with air and forms benzalbenzylamine. It also reacts with carbon dioxide to form its solid carbamic acid salt. It therefore should be stored in a tight closed container for not more than one year. For longer storage, a nitrogen blanket is recommended. In Germany the conditions for storage are classified as 8L (VCI-Lagerklasse).

Purification Methods

Dry it with NaOH or KOH, then distil it under N2, through a column packed with glass helices, taking the middle fraction. Also distil it from zinc dust under reduced pressure. The picrate has m 196o (from EtOH), and the p-toluenesulfonamide has m 116o (from MeOH). [Beilstein 12 IV 2155.]

Benzylamine Preparation Products And Raw materials

Raw materials

Phthalimide Benzyl chloride Ammonium hydroxide Benzaldehyde Hexamethylenetetramine Ammonium bicarbonate

Preparation Products

(R)-3-(Boc-amino)pyrrolidine 2,6-Dimethylpiperazine Ethyl 3-(benzylamino)propanoate 4-(Acetamidomethyl)benzenesulfamide Mafenide hydrochloride N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride 4-N-Boc-4-N-Methyl-aminopiperidine 1-Boc-3-(Aminomethyl)azetidine (S)-1-Benzyl-3-pyrrolidinol (S)-3-Hydroxypyrrolidine hydrochloride (+)-(3R,4R)-BIS(DIPHENYLPHOSPHINO)-1-BENZYLPYRROLIDINE Irbesartan 4-Dimethylaminobenzaldehyde N-BOC-3-AMINOOXETANE-3-CARBOXYLIC ACID BENZYL-(2-METHYLSULFANYL-PYRIMIDIN-4-YL)-AMINE 6-benzylaminopurine 4-(1-BENZYLPIPERIDIN-4-YLOXY)-3,5-DICHLOROBENZENAMINE 4-((4-BENZYLMORPHOLIN-2-YL)METHOXY)-3,5-DICHLOROBENZENAMINE trans-1,4-Diaminocyclohexane Admire 1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOL 1-N-Boc-3-Azetidinecarboxylic acid DL-Aspartic acid 4-(AMINOMETHYL)BENZENESULFONAMIDE 1-BENZYL-3-METHYL-4-PIPERIDONE (R)-3-Hydroxypyrrolidine METHYL 3-AMINOOXETANE-3-CARBOXYLATE N-BENZYLIMINODIACETIC ACID NAPROANILIDE N,N-Dimethylbenzylamine ETHYL 4-PIPERIDONE-3-CARBOXYLATE HYDROCHLORIDE 1-Benzyl-4-piperidone (R)-(+)-1-Benzyl-3-pyrrolidinol (3S,4S)-(-)-1-BENZYL-3,4-BIS(DIPHENYLPHOSPHINO)PYRROLIDINE N'-BENZYL-N,N-DIMETHYLETHYLENEDIAMINE 3-Aminopyrrolidine sodium dibenzyl amine enzene sulfonate Imidacloprid 6-benzylaminopurine hydrochloride
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View Lastest Price from Benzylamine manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Benzylamine 100-46-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28
Hebei Chuanghai Biotechnology Co,.LTD
Product
Benzylamine 100-46-9
Price
US $15.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-20
Wuhan Boyuan Import & Export Co., LTD
Product
Benzylamine 100-46-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000tons
Release date
2023-04-07

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