3-Amino-6-chloro-2-picoline

Product Name: 3-Amino-6-chloro-2-picoline
CAS No.: 164666-68-6
Chemical Name: 3-Amino-6-chloro-2-picoline
Synonyms: 6-chloro-2-methylpyridin-3-amine;3-AMINO-6-CHLORO-2-METHYLPYRIDINE;2-CHLORO-4-METHYLPYRIDIN-3-AMINE;TIMTEC-BB SBB010194;ASINEX-REAG BAS 13794917;3-AMINO-2-CHLORO-4-PICOLINE;5-AMINO-2-CHLORO-6-PICOLINE;3-AMINO-6-CHLORO-2-PICOLINE;2-CHLORO-5-AMINO-6-PICOLINE;3-Amino-6-chloro-2-picoline ,97%
CBNumber: CB5213991
Molecular Formula: C6H7ClN2
Formula Weight: 142.59
MOL File: 164666-68-6.mol

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3-Amino-6-chloro-2-picoline Property

Melting point:: 93-94℃
Boiling point:: 232.49°C (rough estimate)
Density: 1.2124 (rough estimate)
refractive index: 1.4877 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka: 1.79±0.10(Predicted)
form: Solid
color: Pale yellow
CAS DataBase Reference: 164666-68-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T,Xn
Risk Statements: 22-37/38-41-20/21/22
Safety Statements: 26-39-36/37-24/25
RIDADR: 2811
HazardClass: IRRITANT, TOXIC
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: C369830
Product name: 6-Chloro-2-methylpyridin-3-amine
Packaging: 10g
Price: $470
Updated: 2021/12/16

Matrix Scientific

Product number: 024807
Product name: 5-Amino-2-chloro-6-methylpyridine
Purity: 98%
Packaging: 1g
Price: $10
Updated: 2021/12/16

AK Scientific

Product number: J51980
Product name: 3-Amino-6-chloro-2-picoline
Packaging: 1g
Price: $10
Updated: 2021/12/16

AK Scientific

Product number: J51980
Product name: 3-Amino-6-chloro-2-picoline
Packaging: 5g
Price: $20
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK157114
Product name: 3-Amino-6-chloro-2-picoline
Purity: 97%
Packaging: 1g
Price: $35
Updated: 2021/12/16

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3-Amino-6-chloro-2-picoline Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Uses

6-Chloro-2-methylpyridin-3-amine has been used as a reactant in the preparation of Pyrido[3,2-e][1,4]diazepine derivatives with anti-HIV-1-activity.

Synthesis

22280-60-0

164666-68-6

Step 1: Synthesis of 6-chloro-2-methylpyridin-3-amine (44). 2-Chloro-5-nitro-6-methylpyridine (43, 5 g, 29 mmol) was dissolved in ethanol (20 mL) and concentrated hydrochloric acid was added slowly with stirring. Powdered hydrochloric acid (16.2 g, 289 mmol) and additional concentrated hydrochloric acid (20 mL) were added in batches over 30 minutes at room temperature. After addition, stirring was continued for 30 minutes at room temperature. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Water was added to the residue and neutralized with sodium bicarbonate to neutral. Subsequently, ethyl acetate was added for extraction and the two-phase mixture was filtered through diatomaceous earth and washed with ethyl acetate. The organic phase was separated, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate and concentrated to give the target product 44 (4.1 g, 99% yield) as a yellow solid.

References

[1] Patent: WO2017/4608, 2017, A1. Location in patent: Paragraph 0164
[2] Patent: WO2017/4609, 2017, A1. Location in patent: Paragraph 0235
[3] Archiv der Pharmazie, 1995, vol. 328, # 3, p. 247 - 255
[4] Chemistry of Heterocyclic Compounds, 1996, vol. 32, # 10, p. 1173 - 1177
[5] Journal of the American Chemical Society, 1947, vol. 69, p. 63,66

3-Amino-6-chloro-2-picoline Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate 2-Amino-6-methyl-5-nitropyridine Potassium hydroxide 2-Amino-6-methylpyridine tert-Butanol Phosphorus oxitrichloride Sodium borohydride Sodium nitrite Phosphorus pentachloride Nitric acid Methanol Iron Sulfuric acid

Preparation Products

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3-Amino-6-chloro-2-picoline Suppliers

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View Lastest Price from 3-Amino-6-chloro-2-picoline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Amino-6-chloro-2-picoline 164666-68-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Henan Aochuang Chemical Co.,Ltd.

Product: 3-Amino-6-chloro-2-picoline 164666-68-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

Henan Fengda Chemical Co., Ltd

Product: 3-Amino-6-chloro-2-picoline 164666-68-6
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

164666-68-6, 3-Amino-6-chloro-2-picolineRelated Search:

2-(Chloromethyl)pyridine 2-Chloro-5-methylpyridine 4-Aminopyridine 6-Aminocaproic acid 6-Chloro-2-picoline ALTRENOGEST 4-Dimethylaminopyridine 2-Amino-6-methylpyridine 2-Picoline 2-Amino-6-chloropyridine 3-Aminopyridine 2-Chloro-5-chloromethylpyridine 2,6-Lutidine 5-Amino-2-methylpyridine Glycine Tris(hydroxymethyl)aminomethane Difluorochloromethane 6-Chloro-2-methyl-3-nitropyridine

ASINEX-REAG BAS 13794917

2-methyl-3-amino-6-chloropyridine

5-AMINO-2-CHLORO-6-METHYLPYRIDINE

TIMTEC-BB SBB010194

3-AMINO-2-CHLORO-4-PICOLINE

3-AMINO-2-CHLORO-4-METHYLPYRIDINE

3-AMINO-6-CHLORO-2-METHYLPYRIDINE

3-AMINO-6-CHLORO-2-PICOLINE

5-AMINO-2-CHLORO-6-PICOLINE

6-CHLORO-2-METHYL-PYRIDIN-3-YLAMINE

2-CHLORO-4-METHYLPYRIDIN-3-AMINE

2-CHLORO-4-METHYL-PYRIDIN-3-YLAMINE

2-CHLORO-5-AMINO-6-PICOLINE

2-CHLORO-6-METHYL-5-AMINOPYRIDINE

5-Amino-2-chloro-6-methylpyridine (3-Amino-6-chloro-2-methylpyridine)

3-Pyridinamine,6-chloro-2-methyl-(9CI)

6-chloro-2-methylpyridin-3-amine

3-Amino-6-chloro-2-picoline ,97%

2-CHLORO-5-AMINO-6-METHYLPYRIDINE

6-Chloro-2-methyl-3-pyridinamine

6-chloro-2-Methyl-[3]pyridylaMine

3-Pyridinamine, 6-chloro-2-methyl-

3-Amino-6-chloro-2-methylpyridine,95%

3-Amino-6-chloro-2-picoline ISO 9001：2015 REACH

2 - methyl 5 - amino 6 - chloro pyridine

164666-68-6

1092349-78-7

Chloropyridines

Halopyridines

Boronic Acid

Amino-pyridine series

Pyridine series

Pyridines

PYRIDINE

HALIDE