ChemicalBook > CAS DataBase List > 2-CHLORO-4-METHOXYPYRIMIDINE

2-CHLORO-4-METHOXYPYRIMIDINE

Product Name
2-CHLORO-4-METHOXYPYRIMIDINE
CAS No.
22536-63-6
Chemical Name
2-CHLORO-4-METHOXYPYRIMIDINE
Synonyms
2-chloro-4-methoxy pyrimdine;2-Chloro-6-methoxypyrimidine;2-CHLORO-4-METHOXYPYRIMIDINE;2-Chloro-4-methoxy-1,2-diazine;Pyrimidine, 2-chloro-4-methoxy-;2-Chloro-4-methoxypyrimidine 98%;Pyrimidine, 2-chloro-4-methoxy- (6CI,8CI,9CI);2-CHLORO-4-METHOXYPYRIMIDINE ISO 9001：2015 REACH
CBNumber
CB5304318
Molecular Formula
C5H5ClN2O
Formula Weight
144.56
MOL File
22536-63-6.mol
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2-CHLORO-4-METHOXYPYRIMIDINE Property

Melting point:
54-57 °C (lit.)
Boiling point:
96-97 °C(Press: 18 Torr)
Density 
1.292±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
0.07±0.20(Predicted)
form 
Crystalline Powder
color 
White to yellow
InChIKey
BDXYNMVQMBCTDB-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
536458
Product name
2-Chloro-4-methoxypyrimidine
Purity
98%
Packaging
1g
Price
$30
Updated
2023/06/20
Sigma-Aldrich
Product number
536458
Product name
2-Chloro-4-methoxypyrimidine
Purity
98%
Packaging
5g
Price
$59.9
Updated
2023/06/20
TRC
Product number
C367688
Product name
2-Chloro-4-methoxypyrimidine
Packaging
500mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
B391
Product name
2-Chloro-4-methoxypyrimidine
Packaging
1g
Price
$14
Updated
2021/12/16
Matrix Scientific
Product number
083956
Product name
2-Chloro-4-methoxypyrimidine
Purity
97%
Packaging
1g
Price
$19
Updated
2021/12/16
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2-CHLORO-4-METHOXYPYRIMIDINE Chemical Properties,Usage,Production

Uses

2-Chloro-4-methoxypyrimidine is a pharmaceutical intermediate compound used in the preparation of Rilpivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of Human Immunodeficiency Virus (HIV) infections, which prevents the replication of the virus.

Synthesis

2-Chloro-4-methoxypyrimidine is prepared by the reaction of 2,4-Dichloropyrimidine and Sodium Methoxide. The specific synthesis steps are as follows:
To a solution of 2,4-dichloropyrimidine (41.8 g, 280 mmol) in methanol (900 mL)was added a solution of CH3ONa (15.2 g, 280 mmol) in 100 mL methanol at 0 °C. The mixturewas stirred at rt for overnight. The mixture was concentrated under reduce pressure to give awhite solid, which was diluted with water (400mL) and extracted with ethyl acetate (500 mL x3). The combined organic layer was washed with brine, dried, concentrated to give 2-chloro-4-methoxypyrimidine (40 g, yield: 98percent) as white solid. ESI-MS (M+H): 145.0. ‘H NMR (400 MHz, CDC13) (5: 8.30 (d, J= 5.6 Hz ,1H), 6.68 (s, J= 5.6 Hz ,1H), 4.02 (s, 3H).

2-CHLORO-4-METHOXYPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-4-METHOXYPYRIMIDINE Suppliers

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View Lastest Price from 2-CHLORO-4-METHOXYPYRIMIDINE manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-Chloro-4-MethoxypyriMidine 22536-63-6
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-12
Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-4-MethoxypyriMidine 22536-63-6
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-12
LY Global chemicals co.,ltd .
Product
2-CHLORO-4-METHOXYPYRIMIDINE 22536-63-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100kg
Release date
2023-03-19

22536-63-6, 2-CHLORO-4-METHOXYPYRIMIDINERelated Search:

2-Chloro-4-methoxypyridine 2-Chloro-4,6-dimethoxypyrimidine 2,4-Dichloro-6-methoxypyrimidine 2-CHLORO-4-METHOXYPYRIMIDINE 2-Amino-4-chloro-6-methoxypyrimidine 2,4-Dichloro-5-methoxypyrimidine 4-Amino-6-chloro-2-methoxypyrimidine 4-AMINO-6-CHLORO-5-METHOXYPYRIMIDINE Chlorimuron 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE 1-[2-(Ethoxycarbonyl)phenylsulfonyl]-3-(4-chloro-6-methoxypyrimidine-2-yl)urea 5-CHLORO-2-METHOXYPYRIMIDINE,PURITY:95% MIN(HPLC) 2-Methoxy-4,6-dichloropyrimidine 5-CHLORO-2-METHOXYPYRIMIDINE-4-CARBOXYLIC ACID 4-CHLORO-6-METHOXYPYRIMIDINE 2-Chloro-6-methoxyisonicotinoyl chloride 4,6-Dichloro-5-methoxypyrimidine 2-Chloro-5-methoxypyrimidine

  • 2-CHLORO-4-METHOXYPYRIMIDINE
  • Pyrimidine, 2-chloro-4-methoxy- (6CI,8CI,9CI)
  • 2-Chloro-6-methoxypyrimidine
  • 2-Chloro-4-methoxy-1,2-diazine
  • 2-Chloro-4-methoxypyrimidine 98%
  • Pyrimidine, 2-chloro-4-methoxy-
  • 2-CHLORO-4-METHOXYPYRIMIDINE ISO 9001：2015 REACH
  • 2-chloro-4-methoxy pyrimdine
  • 22536-63-6
  • Building Blocks
  • Pyrimidines
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Heterocycle-Pyrimidine series
  • Pyrazines, Pyrimidines & Pyridazines
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • PyrimidinesHeterocyclic Building Blocks
  • pharmacetical
  • Halides
  • Pyrazines, Pyrimidines & Pyridazines
  • Pyrimidines
  • PYRIMIDINE