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Pomalidomide-PEG4-CO2H

Product Name
Pomalidomide-PEG4-CO2H
CAS No.
2138440-81-8
Chemical Name
Pomalidomide-PEG4-CO2H
Synonyms
Pomalidomide-PEG4-COOH;Poma-PEG4-COOH;Pomalidomide-PEG4-CO2H;POMALIDOMIDE-PEG4-CO 2 H;Pomalidomide 4'-PEG4-acid;Thalidomide-NH-PEG4-C2-COOH;1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid;1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid;1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxapentadecan-15-oic acid;Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-
CBNumber
CB54846410
Molecular Formula
C24H31N3O10
Formula Weight
521.52
MOL File
2138440-81-8.mol
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Pomalidomide-PEG4-CO2H Property

Boiling point:
773.6±60.0 °C(Predicted)
Density 
1.385±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.28±0.10(Predicted)
form 
Viscous Liquid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901824
Product name
Pomalidomide-PEG4-CO2H
Packaging
50MG
Price
$358.2
Updated
2024/03/01
Iris Biotech GmbH
Product number
PTC1180
Product name
Pomalidomide-PEG4-COOH
Packaging
50mg
Price
$594
Updated
2021/12/16
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Pomalidomide-PEG4-CO2H Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG4-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition and E3 ligase ligand.

storage

Desiccate at RT

Pomalidomide-PEG4-CO2H Preparation Products And Raw materials

Raw materials

Preparation Products

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Pomalidomide-PEG4-CO2H Suppliers

Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
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View Lastest Price from Pomalidomide-PEG4-CO2H manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Pomalidomide-PEG4-COOH 2138440-81-8
Price
US $0.00/mg
Min. Order
250mg
Purity
>98.00%
Supply Ability
250mg
Release date
2024-04-01

2138440-81-8, Pomalidomide-PEG4-CO2HRelated Search:


  • POMALIDOMIDE-PEG4-CO 2 H
  • Pomalidomide-PEG4-CO2H
  • Pomalidomide-PEG4-COOH
  • 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid
  • Thalidomide-NH-PEG4-C2-COOH
  • Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-
  • 1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid
  • 1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
  • Poma-PEG4-COOH
  • Pomalidomide 4'-PEG4-acid
  • 1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxapentadecan-15-oic acid
  • 2138440-81-8
  • peg