ChemicalBook > CAS DataBase List > 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- Product Name
- 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- CAS No.
- 2093416-31-8
- Chemical Name
- 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- Synonyms
- Pomalidomide-PEG3-C2-NH2;Thalidomide-4-NH-PEG3-C2-NH2;Cereblon Ligand-Linker Conjugates 5;E3 ligase Ligand-Linker Conjugates 30;4-[[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
- CBNumber
- CB54849370
- Molecular Formula
- C21H28N4O7
- Formula Weight
- 448.47
- MOL File
- 2093416-31-8.mol
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4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Property
- Boiling point:
- 694.2±55.0 °C(Predicted)
- Density
- 1.361±0.06 g/cm3(Predicted)
- pka
- 10.74±0.40(Predicted)
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N-Bromosuccinimide Price
DC Chemicals
- Product number
- 027583
- Product name
- E3ligaseLigand-LinkerConjugates30
- Packaging
- 001
- Price
- $550
- Updated
- 2021/12/16
DC Chemicals
- Product number
- 027583
- Product name
- E3ligaseLigand-LinkerConjugates30
- Packaging
- 002
- Price
- $950
- Updated
- 2021/12/16
DC Chemicals
- Product number
- 027583
- Product name
- E3ligaseLigand-LinkerConjugates30
- Packaging
- 003
- Price
- $1900
- Updated
- 2021/12/16
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4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties,Usage,Production
Description
Pomalidomide-PEG3-C2-NH2 is a Pomalidomide-based cereblon ligand with a linker, which is a useful precursor for synthesis of PROTAC degraders. Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. PROTAC degraders are usually heterobifunctional small molecules consisting of two ligands joined by a linker: one ligand recruits and binds a protein of interest (POI) while the other recruits and binds an E3 ubiquitin ligase. Simultaneous binding of the POI and ligase by the PROTAC induces ubiquitylation of the POI and its subsequent degradation by the ubiquitin–proteasome system (UPS), after which the PROTAC is recycled to target another copy of the POI.
4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Suppliers
- Tel
- 16314854226; +16314854226
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19743
- Advantage
- 58
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19892
- Advantage
- 58
2093416-31-8, 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneRelated Search:
E3 ligase Ligand-Linker Conjugates 50
Pomalidomide-PEG3-CO2H
Pomalidomide-PEG2-N3
Pomalidomide-PEG4-azide
Pomalidomide-PEG2-butyl iodide
E3 Ligase Ligand-Linker Conjugates 22
Pomalidomide-PEG4-CO2H
E3 Ligase Ligand-Linker Conjugates 1
POMALIDOMIDE-PEG2-CO2H
Pomalidomide-PEG1-azide
Pomalidomide-PEG5-CO2H
POMALIDOMIDE-PEG1-CO2H
Pomalidomide-O-C4-NH2
Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]-
Pomalidomide-PEG3-N3
Pomalidomide-PEG6-butyl iodide